NDLI: Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of Multiple Myeloma

Content Provider	Springer Nature Link
Author	Sikka, Sakshi Shanmugam, Muthu K. Kannaiyan, Radhamani Surana, Rohit Shin, Eun Myoung Kumar, Alan Prem Sethi, Gautam Ahn, Kwang Seok
Copyright Year	2013
Abstract	Multiple myeloma (MM) is a malignant plasma cell tumor often arising in the bone marrow and is the most common non-Hodgkin’s haematological malignancy contributing 13 % of all malignancy and 1 % of neoplasia. MM arises from a pre-malignant condition known as ‘monoclonal gammapathy of undermined significance’. The aberrant antibodies that are produced leads to dysregulated humoral immunity. Studies in the last few years have revealed that various pro-inflammatory signaling pathways including nuclear factor-kappaB (NF-κB), signal transducer and activator of transcription 3 (STAT3), activator protein 1 (AP-1), phosphatidylinositol-3-kinase (PI3K/AKT), receptor Met and its ligand hepatocyte growth factor, and Wnt-β catenin play a pivotal role in the initiation and progression of MM. These signaling pathways can be induced by different pro-inflammatory cytokines and chemokines in MM cells. Hence, it is imperative to clearly dissect the role of various pro-inflammatory signaling pathways for the better understanding of the disease process and also for developing effective therapeutic interventions. In this review, we comprehensively analyze the detailed role of various pro-inflammatory signaling pathways involved in myeloma-genesis and its progression. Also, we discuss in detail the potential contribution of distinct inhibitors of pro-inflammatory signaling pathways derived from the natural sources that can be utilized both for the prevention and the treatment of MM.
Starting Page	79
Ending Page	106
Page Count	28
File Format	PDF
ISSN	15687767
Journal	Phytochemistry Reviews
Volume Number	13
Issue Number	1
e-ISSN	1572980X
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-04-17
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Multiple myeloma Natural agents Signal transduction Apoptosis Plant Sciences Plant Genetics & Genomics Biochemistry Organic Chemistry Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Plant Science Biotechnology

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