NDLI: Suppression of Agglomeration in Fluidized Bed Coating. III. Hofmeister Series in Suppression of Particle Agglomeration

Content Provider	Springer Nature Link
Author	Naka, Tatsu Yuasa, Hiroshi Kanaya, Yoshio
Copyright Year	1999
Abstract	Purpose. Fourteen kinds of salts consisting of various cations and anions in the Hofmeister series were used as additives for suppression of particle agglomeration in the fluidized bed coating. We attempted to clarify the relationship between the suppression effect of the salts and the Hofmeister series of their consistent ions. Methods. Fluidized bed coating was carried out with hydroxypropyl-methyl cellulose (HPMC) aqueous coating solution containing the salts and Celphere® as core particles. To elucidate the salting-out power of the salts for HPMC, the transmittance of the coating solutions at 600 nm was measured at various temperatures and the phase separation temperature (T$_{PS}$) was determined from the values at 50% transmittance. Results. A high suppression effect was observed when the salts including high order ions in the Hofmeister series were added to the coating solution. T$_{PS}$ decreased in the presence of the salts except for sodium iodide and sodium thiocyanate and lowered with the higher order ion in the Hofmeister series. The particle agglomeration was suppressed with decrease in T$_{PS}$ of the HPMC aqueous coating solution. Conclusions. It has been suggested that the suppression effect of a salt on the particle agglomeration depended on the salting-out power of the salt. We regard sodium citrate and potassium citrate as very useful pharmaceutical additives for the suppression of particle agglomeration in actual pharmaceutical coating.
Starting Page	1616
Ending Page	1620
Page Count	5
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	16
Issue Number	10
e-ISSN	1573904X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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