NDLI: Overcoming Glucocorticoid Resistances and Improving Antitumor Therapies: Lipid and Polymers Carriers

Content Provider	Springer Nature Link
Author	Martín Sabroso, C. More Ortega, A. J. Aparicio Blanco, J. Fraguas Sánchez, A. I. Ca Abad, M. F. Torres Suárez, A. I.
Copyright Year	2014
Abstract	To improve chemotherapy protocols of lymphoid malignancies, by using polymeric and lipid microparticles as controlled delivery systems of dexamethasone, part of all combined chemotherapy protocols for its strong-inducing effect on malignant lymphoblasts.Polymeric microparticles were prepared by the oil-in-water-emulsion cosolvent evaporation method, andlipid microparticles by spray drying. Their cytotoxic effects on GC-sensitive PC12 cells and GC-resistant PC3 cells were characterized by cell proliferation and apoptosis assays.Both elaboration methods rendered optimal-sized microparticles for parenteral administration with high drug loading. In vitro assays showed sustained dexamethasone release from polymeric microparticles over a month, whereas 100% dexamethasone release from lipid microparticles was achieved within 24 h. Similar PC12 cell death to that obtained with dexamethasone solution administered every 48 h was achieved with dexamethasone polymeric microparticles in 26-days assays. Dexamethasone solution and loaded polymeric microparticles induced apoptosis around 15.8 and 19.9%, respectively, after 2 days of incubation. Lipid microparticles increased further apoptosis induction in PC12 cells and, unlike dexamethasone solution and polymeric microparticles, showed antiproliferative effects on PC3 cells.Dexamethasone polymeric microparticles constitute an alternative to current dexamethasone administration systems in combined chemotherapy, whereas dexamethasone lipid microparticles represent a potential tool to revert glucocorticoid resistance.
Starting Page	968
Ending Page	985
Page Count	18
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	32
Issue Number	3
e-ISSN	1573904X
Language	English
Publisher	Springer US
Publisher Date	2014-09-12
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects

Overcoming Poor Tabletability of Pharmaceutical Crystals by Surface Modification

Lactose Composite Carriers for Respiratory Delivery

Intratumoral Drug Delivery with Nanoparticulate Carriers

Novel Long-Circulating Lipid Nanocapsules

Controlled Nucleation of Lipid Nanoparticles

Inhalable Microparticles as Carriers for Pulmonary Delivery of Thymopentin-Loaded Solid Lipid Nanoparticles

PH-Responsive Nano Carriers for Doxorubicin Delivery

Antibodies as Drug Carriers. II. For Proteins

Overcoming Glucocorticoid Resistances and Improving Antitumor Therapies: Lipid and Polymers Carriers

Similar Documents

Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects

Overcoming Poor Tabletability of Pharmaceutical Crystals by Surface Modification

Lactose Composite Carriers for Respiratory Delivery

Intratumoral Drug Delivery with Nanoparticulate Carriers

Novel Long-Circulating Lipid Nanocapsules

Controlled Nucleation of Lipid Nanoparticles

Inhalable Microparticles as Carriers for Pulmonary Delivery of Thymopentin-Loaded Solid Lipid Nanoparticles

PH-Responsive Nano Carriers for Doxorubicin Delivery

Antibodies as Drug Carriers. II. For Proteins

Overcoming Glucocorticoid Resistances and Improving Antitumor Therapies: Lipid and Polymers Carriers