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Simultaneous FTIR Spectroscopic Imaging and Visible Photography to Monitor Tablet Dissolution and Drug Release

Content Provider	Springer Nature Link
Author	Kazarian, Sergei G. Weerd, Jaap
Copyright Year	2007
Abstract	Previous studies of hydroxypropyl methylcellulose (HPMC)-based tablet during exposure to water showed a number of ‘fronts’ moving into the tablet but led to contradictory interpretations. These fronts are related to water penetration into and dissolution of the tablet, but the exact nature can not be derived from visible photographic evidence. A method to study tablet dissolution simultaneously by Fourier transform infrared-attenuated total reflection (FTIR-ATR) imaging and macro-photography can assist in providing correct interpretation of the observed fronts.Therefore, the combination of macro-photography and FTIR-ATR spectroscopic imaging was developed and used to interpret the physical changes leading to the observed fronts. Buflomedyl pyridoxal phosphate (BPP), a coloured drug, was used as a model drug.The quantitative results obtained by FTIR-ATR imaging enabled the attribution of the three observed fronts (inside to outside) to: (1) true water penetration, possibly combined with (partial) dissolution of buflomedyl pyridoxal phosphate (BPP); (2) total gellification of HPMC; (3) erosion front.The method to study dissolution of a tablet simultaneously by FTIR-ATR imaging and macro-photography has been developed and used to obtain reliable interpretation of the fronts observed during tablet dissolution.
Starting Page	853
Ending Page	860
Page Count	8
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	25
Issue Number	4
e-ISSN	1573904X
Language	English
Publisher	Springer US
Publisher Date	2007-07-06
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ATR controlled release dissolution drug release FT-IR imaging gel hydroxypropyl methylcellulose multivariate analysis visible photography Biomedical Engineering Medical Law Biochemistry Pharmacy Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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