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| Content Provider | Springer Nature Link |
|---|---|
| Author | Hajri, Amor Damgé, Christiane |
| Copyright Year | 1998 |
| Abstract | Purpose. To investigate the effects of increasing concentrations of cholecystokinin octapeptide (CCK-8) on a pancreatic acinar adenocarcinoma. Methods. Growth of the tumour was estimated in vivo on rats bearing a subcutaneous pancreatic carcinoma, and in vitro on primary cultured tumour cells. CCK receptors were characterized by binding assays. Results. CCK-8, administered for 12 successive days, exerted a biphasic action on tumour growth: a dose-dependent stimulation with low doses (0.1 and 0.5 μg/kg) and inhibition with high doses (2 and 4 μg/ kg) as shown by respective increases and decreases in tumor volume, protein, RNA and amylase contents. In cell cultures, [$^{3}$H]thymidine incorporation was dose-dependently increased with 10$^{−10}$ to 10$^{−8}$ M CCK-8 and inhibited with 10$^{−7}$ M. Both effects were completely suppressed by the CCK-receptor antagonists CR 1409 and L 364,718 (10$^{−4}$ M). Binding studies showed the overexpression of two classes of CCK-A receptors of low and high affinity when compared to the normal pancreas which was less sensitive to CCK-8. Conclusions. CCK-8 exerts a biphasic growth response on the acinar pancreatic carcinoma, mediated by two classes of CCK-A receptors overexpressed in the tumour. |
| Starting Page | 1767 |
| Ending Page | 1774 |
| Page Count | 8 |
| File Format | |
| ISSN | 07248741 |
| Journal | Pharmaceutical Research |
| Volume Number | 15 |
| Issue Number | 11 |
| e-ISSN | 1573904X |
| Language | English |
| Publisher | Kluwer Academic Publishers-Plenum Publishers |
| Publisher Date | 1998-01-01 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science |
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