NDLI: Location-Dependent Analysis of Porosity and Pore Direction in Tablets

Content Provider	Springer Nature Link
Author	Wu, Yu San Frijlink, Henderik W. Vliet, Lucas J. Stokroos, Ietse Voort Maarschalk, Kees
Copyright Year	2005
Abstract	Several phenomena in tablets indicate that an inhomogeneous pore distribution is formed during the compaction process. Examples are lamination and the capping of corners. In order to gain an understanding of the relation between structure and compact properties, analyzing the structure in a location dependent manner would be extremely useful. Our aim was to visualize and to quantitatively analyze the pore distribution in compacts.This was done by embedding a cubic (sodium chloride) compact with polymer, allowing the compact to be cut without disrupting the structure. By doing so, it was possible to make scanning electron microscopic images from different angles at different locations in the compact. These images were made binary with a two-means cluster algorithm (Isodata) after which the porosity could be calculated. Counting the number of transitions from the pixels in the pores to the pixels in the sodium chloride particles in two perpendicular directions allows us to construct a measure for the anisotropic connectivity of the particles.The results show an increase in porosity toward the bottom of the compact and showed a preferred orientation of the pores in the direction of compression.The proposed method is suitable for analyzing the pore distribution quantitatively and for evaluating anisotropy.
Starting Page	1399
Ending Page	1405
Page Count	7
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	22
Issue Number	8
e-ISSN	1573904X
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-08-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	anisotropy compaction imaging pore characterization pore structure Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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