NDLI: Surface Crystallization of Indomethacin Below T $

Content Provider	Springer Nature Link
Author	Wu, Tian Yu, Lian
Copyright Year	2006
Abstract	To study the surface crystallization of indomethacin (IMC) below T $_{g}$ and its effects on the kinetics of overall crystallization.Crystal growth rates in liquid layers formed between microscope cover glasses were measured with the top cover glass in place and removed. Polymorphs were identified by powder X-ray diffraction, Raman microscopy, and melting-point determination by hot-stage microscopy. Surface crystals were identified by scratching the sample surface, by cutting the sample to expose its interior, and by analyzing the intensity of X-ray diffraction. Amorphous IMC particles of different sizes were stored at 40°C (T $_{g}$−2°C) and analyzed at different times by differential scanning calorimetry to obtain the kinetics of crystallization.Crystal growth of IMC below T $_{g}$ at the free surface was approximately two orders of magnitude faster than that in the bulk, resulting in a surface layer of crystals around a slower-crystallizing interior. Surface crystallization yielded mainly the γ polymorph. Amorphous IMC powders showed rapid initial crystallization at 40°C, but the crystallization abruptly slowed down at “saturation levels” below 100%; the larger the particles, the lower the “saturation level.”The faster surface crystallization of IMC than the bulk crystallization leads to unusual crystallization kinetics wherein a rapid initial increase of crystallinity is followed by an abrupt slowdown of crystallization. Surface crystallization should be distinguished from bulk crystallization in modeling and controlling the crystallization of amorphous solids.
Starting Page	2350
Ending Page	2355
Page Count	6
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	23
Issue Number	10
e-ISSN	1573904X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-08-23
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	amorphous solid crystallization kinetics glass transition indomethacin physical stability surface crystallization Biomedical Engineering Medical Law Biochemistry Pharmacy Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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