NDLI: A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span

Content Provider	Springer Nature Link
Author	Wang, Chenguang Peeters, Mariska Y. M. Allegaert, Karel Blussé van Oud Alblas, Heleen J. Krekels, Elke H. J. Tibboel, Dick Danhof, Meindert Knibbe, Catherijne A. J.
Copyright Year	2012
Abstract	To explore different allometric equations for scaling clearance across the human life-span using propofol as a model drug.Data from seven previously published propofol studies ((pre)term neonates, infants, toddlers, children, adolescents and adults) were analysed using NONMEM VI. To scale clearance, a bodyweight-based exponential equation with four different structures for the exponent was used: (I) 3/4 allometric scaling model; (II) mixture model; (III) bodyweight-cut-point separated model; (IV) bodyweight-dependent exponent model.Model I adequately described clearance in adults and older children, but overestimated clearance of neonates and underestimated clearance of infants. Use of two different exponents in Model II and Model III showed significantly improved performance, but yielded ambiguities on the boundaries of the two subpopulations. This discontinuity was overcome in Model IV, in which the exponent changed sigmoidally from 1.35 at a hypothetical bodyweight of 0 kg to a value of 0.56 from 10 kg onwards, thereby describing clearance of all individuals best.A model was developed for scaling clearance over the entire human life-span with a single continuous equation, in which the exponent of the bodyweight-based exponential equation varied with bodyweight.
Starting Page	1570
Ending Page	1581
Page Count	12
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	29
Issue Number	6
e-ISSN	1573904X
Language	English
Publisher	Springer US
Publisher Date	2012-01-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacy Medical Law Pharmacology/Toxicology Biomedical Engineering Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span (2011)

Allometric Pharmacokinetic Scaling: Towards the Prediction of Human Oral Pharmacokinetics

Determination of a Human Hepatic Microsomal Scaling Factor for Predicting in Vivo Drug Clearance

Accuracy and Precision of Pharmacodynamic Exponent

Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model

Influence of Permeant Lipophilicity on Permeation Across Human Sclera

Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span

Similar Documents

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span (2011)

Allometric Pharmacokinetic Scaling: Towards the Prediction of Human Oral Pharmacokinetics

Determination of a Human Hepatic Microsomal Scaling Factor for Predicting in Vivo Drug Clearance

Accuracy and Precision of Pharmacodynamic Exponent

Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model

Influence of Permeant Lipophilicity on Permeation Across Human Sclera

Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span