NDLI: Influence of Lipid Nanocapsules Composition on Their Aptness to Freeze-Drying

Content Provider	Springer Nature Link
Author	Dulieu, Claire Bazile, Didier
Copyright Year	2005
Abstract	To link the aptness to freeze-drying and the stability under storage to the topology of lipid nanocapsules.The aptness to freeze-drying and the stability under storage of lipid nanocapsules prepared from different compositions with a lecithin content in the 2–20% range were estimated from the preservation of the physical structure, preventing the leakage of the oily phase. The influence of the outer shell composition and of the physical characteristics (investigated by photon correlation spectroscopy and differential scanning calorimetry) on the physical stability was correlated to the topology of the nanoparticulate carrier.Confirming the assumption that lecithin confers hardness to the outer shell of lipid nanocap-sules, this study shows that the aptness to freeze-drying and the stability under storage depend on the Solutol®/lecithin (S/L) ratio in the formulation. The DSC study points out a complexation between lecithin and trehalose, the cryoprotectant, reinforcing the stabilising properties of lecithin.This paper is a contribution to methodological development of the formulation of lipid nanocapsules, with a special emphasis on the aptness to freeze-drying and the stability under storage.
Starting Page	285
Ending Page	292
Page Count	8
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	22
Issue Number	2
e-ISSN	1573904X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2005-02-24
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	formulation freeze-drying lecithin lipid nanocapsules stability under storage thermal analysis Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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