NDLI: Functional Impairment of Sinusoidal Membrane Transport of Organic Cations in Rats with CCl4-Induced Hepatic Failure

Content Provider	Springer Nature Link
Author	Hong, Soon Sun Chung, Suk Jae Shim, Chang Koo
Copyright Year	2000
Abstract	Purpose. The effect of CCl$_{4}$-induced experimental hepatic failure(EHF) on the sequential hepatobiliary transport of model organiccations (OCs), triethylmethylammonium (TEMA), and tributylmethylammonium (TBuMA), was investigated in rats. Methods. EHF was induced by an i.p. injection of CCl$_{4}$ at a dose of1 ml/kg 24 hr prior to the transport study. The cumulative in vivobiliary excretion, in vitro hepatic uptake by isolated hepatocytes,in vitro efflux (i.e., release) from hepatocytes, andin vivo hepatobiliary excretion clearance were measured for normal and CCl$_{4}$-EHF rats. Results. The CCl$_{4}$-EHF decreased the apparentin vivo biliary clearance (CL$_{o}$) and the in vitromaximum uptake rate (V$_{max, uptake}$) of TBuMA by 66 and 48%,respectively. The CCl$_{4}$-EHF had no effect on the CL$_{o}$of TEMA, but decreased both the V$_{max, uptake}$ (59%) and thein vitromaximum hepatic efflux rate (Vmax, efflux) of TEMA (80%). On thecontrary, the CCl$_{4}$-EHF had no influence on the in vivohepatobiliaryexcretion clearance (CL$_{exc}$) of both OCs. Conclusions. Transport systems for the OCs on the sinusoidal membrane(uptake and/or efflux), rather than those on the bile canalicularmembrane (excretion) appear to be prone to damage by the CCl$_{4}$-EHF.
Starting Page	833
Ending Page	838
Page Count	6
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	17
Issue Number	7
e-ISSN	1573904X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2000-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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