NDLI: Subcutaneous Administration of Superoxide Dismutase Entrapped in Long Circulating Liposomes: In Vivo Fate and Therapeutic Activity in an Inflammation Model

Content Provider	Springer Nature Link
Author	Corvo, M. Luísa Boerman, Otto C. Oyen, Wim J. G. Jorge, Joáo C. S. Cruz, M. Eugénia M. Crommelin, Daan J. A. Storm, Gert
Copyright Year	2000
Abstract	Purpose. We are exploring liposomal delivery with the aim to changethe pharmacokinetics and biodistribution of SOD to increase itstherapeutic activity. From a practical point of view, a convenient route ofadministration would be the subcutaneous (s.c.) route. Liposomal sizehas been shown to be the most important factor influencing the rateand extent of drainage of liposomes from the s.c. injection site. Methods. To monitor the in vivo fate of the subcutaneous administeredSOD-containing liposomes in rats with a chronic arthritis inflammation,the liposomes were labeled by the co-encapsulation of the$^{111}$In-DTPA complex in the internal water space. Results. Over the initial 10h-observation period post-injection, thesmall-sized poly(ethyleneglycol)-liposomes (mean size about 110 nm)left the site of injection to a 2-fold higher extent (45% of the injecteddose) as compared to large-sized poly(ethyleneglycol)-liposomes(mean size about 450 nm). Small-sized liposomes gave a 17-fold higheruptake in the inflamed foot than the large-sized liposomes. Comparingthe localization in the inflamed foot with the non-inflamed foot, uptakewas more than 15-fold higher for the small-sized liposomes ascompared to the large-sized liposomes. After s.c. administration,small-sized SOD-liposomes showed substantial higher activity thanlarge-sized SOD-liposomes. S.C. administration of small-sizedSOD-liposomes is equally effective as i.v. administration of the same liposomes.I.V. administration of the large-sized SOD-liposomes yielded asignificantly higher activity as compared to s.c. administration. Conclusions. These results indicate that small-sized poly(ethyleneglycol)-liposomes can be used for the targeting of SOD to arthritic sitesafter subcutaneous administration.
Starting Page	600
Ending Page	606
Page Count	7
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	17
Issue Number	5
e-ISSN	1573904X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2000-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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