NDLI: How did Metabolism and Genetic Replication Get Married?

Content Provider	Springer Nature Link
Author	rris, Vic Loutelier Bourhis, Corinne Thierry, Alain
Copyright Year	2012
Abstract	In addressing the question of the origins of the relationship between metabolism and genetic replication, we consider the implications of a prebiotic, fission-fusion, ecology of composomes. We emphasise the importance of structures and non-specific catalysis on interfaces created by structures. From the assumption that the bells of the metabolism-replication wedding still echo in modern cells, we argue that the functional assemblies of macromolecules that constitute hyperstructures in modern bacteria are the descendants of composomes and that interactions at the hyperstructure level control the cell cycle. A better understanding of the cell cycle should help understand the original metabolism-replication marriage. This understanding requires new concepts such as metabolic signalling, metabolic sensing and Dualism, which entails the cells in a population varying the ratios of equilibrium to non-equilibrium hyperstructures so as to maximise the chances of both survival and growth. A deeper understanding of the coupling between metabolism and replication may also require a new view of cell cycle functions in creating a coherent diversity of phenotypes and in narrowing the combinatorial catalytic space. To take these ideas into account, we propose the Accordion model in which a dynamic interface between lipid domains catalysed monomer to polymer reactions and became decorated with peptides and nucleotides that favoured their own catalysis. In this model, metabolism, replication, differentiation and division all began together at the interface between extended equilibrium structures within protocells or composomes.
Starting Page	487
Ending Page	495
Page Count	9
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	42
Issue Number	5
e-ISSN	15730875
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-10-14
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	DNA replication Origin of life Catalysis Membrane Metabolite Cell division Life Sciences Astrophysics and Astroparticles Earth Sciences Astronomy, Observations and Techniques Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

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