NDLI: Predicting Thermodynamic Behaviors of Non-Protein Amino Acids as a Function of Temperature and pH

Content Provider	Springer Nature Link
Author	Kitadai, rio
Copyright Year	2015
Abstract	Why does life use α-amino acids exclusively as building blocks of proteins? To address that fundamental question from an energetic perspective, this study estimated the standard molal thermodynamic data for three non-α-amino acids (β-alanine, γ-aminobutyric acid, and ε-aminocaproic acid) and α-amino-n-butyric acid in their zwitterionic, negative, and positive ionization states based on the corresponding experimental measurements reported in the literature. Temperature dependences of their heat capacities were described based on the revised Helgeson–Kirkham–Flowers (HKF) equations of state. The obtained dataset was then used to calculate the standard molal Gibbs energies (∆G $^{o}$) of the non-α-amino acids as a function of temperature and pH. Comparison of their ∆G $^{o}$ values with those of α-amino acids having the same molecular formula showed that the non-α-amino acids have similar ∆G $^{o}$ values to the corresponding α-amino acids in physiologically relevant conditions (neutral pH, <100 °C). In acidic and alkaline pH, the non-α-amino acids are thermodynamically more stable than the corresponding α-ones over a broad temperature range. These results suggest that the energetic cost of synthesis is not an important selection pressure to incorporate α-amino acids into biological systems.
Starting Page	3
Ending Page	18
Page Count	16
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	46
Issue Number	1
e-ISSN	15730875
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-08-19
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Abiotic organic synthesis Origin of life Chemical evolution Life Sciences Astrophysics and Astroparticles Earth Sciences Astronomy, Observations and Techniques Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

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