NDLI: Question 5: On the Chemical Reality of the RNA World

Content Provider	Springer Nature Link
Author	Lucrezia, Davide Anella, Fabrizio Chiarabelli, Cristia
Copyright Year	2007
Abstract	The discovery of catalytic RNA has revolutionised modern molecular biology and bears important implications for the origin of Life research. Catalytic RNA, in particular self-replicating RNA, prompted the hypothesis of an early “RNA world” where RNA molecules played all major roles such information storage and catalysis. The actual role of RNA as primary actor in the origin of life has been under debate for a long time, with a particular emphasis on possible pathways to the prebiotic synthesis of mononucleotides; their polymerization and the possibility of spontaneous emergence of catalytic RNAs synthesised under plausible prebiotic conditions. However, little emphasis has been put on the chemical reality of an RNA world; in particular concerning the chemical constrains that such scenario should have met to be feasible. This paper intends to address those concerns with regard to the achievement of high local RNA molecules concentration and the aetiology of unique sequence under plausible prebiotic conditions.
Starting Page	379
Ending Page	385
Page Count	7
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	37
Issue Number	4-5
e-ISSN	15730875
Language	English
Publisher	Springer Netherlands
Publisher Date	2007-06-27
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Origin of life RNA world Prebiotic synthesis of mononucleotides RNA sequence space RNA compartmentation Biochemistry Astronomy Geosciences Astrophysics Life Sciences
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

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