NDLI: The Evolution of Acetyl-CoA Synthase

Please wait, while we are loading the content...

The Rates of Hydrolysis of Thymidyl-3′, 5′-Thymidine-H-Phosphonate: The Possible Role of Nucleic Acids Linked by Diesters of Phosphorous Acid in the Origins of Life

Effect of Inhibitors on the Montmorillonite Clay-Catalyzed Formation of RNA: Studies on the Reaction Pathway

The Evolution of Acetyl-CoA Synthase

Contributions of Icy Planetesimals to the Earth's Early Atmosphere

Exo/Astrobiology in Europe

Origins of Life and Evolution of Biospheres : Volume 31, Issue 3, June 2001

Origins of Life and Evolution of Biospheres : Volume 31, Issue 1-2, February 2001

Origins of Life and Evolution of Biospheres : Volume 30

Origins of Life and Evolution of Biospheres : Volume 29

Origins of Life and Evolution of Biospheres : Volume 28

Origins of Life and Evolution of Biospheres : Volume 27

The Evolution of Acetyl-CoA Synthase

Content Provider	Springer Nature Link
Author	Lindahl, Paul A. Chang, Belinda
Copyright Year	2001
Abstract	Acetyl-coenzyme A synthases (ACS) are Ni–Fe–S containingenzymes found in archaea and bacteria. They are divisible into 4 classes. Class I ACS's catalyze the synthesis of acetyl-CoAfrom CO$_{2}$ + 2e$^{-}$, CoA, and a methyl group, and contain5 types of subunits (α, β, γ, δ, and ε). Class II enzymes catalyze essentially the reversereaction and have similar subunit composition. Class III ACS'scatalyze the same reaction as Class I enzymes, but use pyruvateas a source of CO$_{2}$ and 2e$^{-}$, and are composed of 2 autonomous proteins, an α$_{2}$β$_{2}$ tetramerand a γδ heterodimer. Class IV enzymes catabolize CO to CO$_{2}$ and are α-subunit monomers. Phylogeneticanalyses were performed on all five subunits. ACS α sequences divided into 2 major groups, including Class I/II sequences and Class III/IV-like sequences. Conserved residuesthat may function as ligands to the B- and C-clusters wereidentified. Other residues exclusively conserved in Class I/IIsequences may be ligands to additional metal centers in Class I and II enzymes. ACS β sequences also separated into twogroups, but they were less divergent than the α's, and the separation was not as distinct. Class III-like β sequences contained ∼300 residues at their N-termini absent in Class I/II sequences. Conserved residues identifiedin β sequences may function as ligands to active siteresidues used for acetyl-CoA synthesis. ACS γ-sequencesseparated into 3 groups (Classes I, II, and III), while δ-sequences separated into 2 groups (Class I/II and III). These groups are less divergent than those of α sequences. ACS ε-sequence topology showed greaterdivergence and less consistency vis-à-vis the other subunits, possibly reflecting reduced evolutionary constraintsdue to the absence of metal centers. The α subunit phylogeny may best reflect the functional diversity of ACS enzymes. Scenarios of how ACS and ACS-containing organisms mayhave evolved are discussed.
Starting Page	403
Ending Page	434
Page Count	32
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	31
Issue Number	4-5
e-ISSN	15730875
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2001-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Organic Chemistry Geochemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

EVOLUTIONARY CONSIDERATION ON 5-AMINOLEVULINATE SYNTHASE IN NATURE

Directed Molecular Evolution

The Lipid World

State of the Journal

Prebiotic transamination

Defining ‘Life’

Electronic Publication

THE EARLY SOLAR SYSTEM

Prebiotic phosphorus chemistry reconsidered

The Evolution of Acetyl-CoA Synthase

Similar Documents

EVOLUTIONARY CONSIDERATION ON 5-AMINOLEVULINATE SYNTHASE IN NATURE

Directed Molecular Evolution

The Lipid World

State of the Journal

Prebiotic transamination

Defining ‘Life’

Electronic Publication

THE EARLY SOLAR SYSTEM

Prebiotic phosphorus chemistry reconsidered

The Evolution of Acetyl-CoA Synthase