NDLI: Two Perspectives on the Origin of the Standard Genetic Code

Content Provider	Springer Nature Link
Author	Sengupta, Supratim Aggarwal, Neha Bandhu, Ashutosh Vishwa
Copyright Year	2015
Abstract	The origin of a genetic code made it possible to create ordered sequences of amino acids. In this article we provide two perspectives on code origin by carrying out simulations of code-sequence coevolution in finite populations with the aim of examining how the standard genetic code may have evolved from more primitive code(s) encoding a small number of amino acids. We determine the efficacy of the physico-chemical hypothesis of code origin in the absence and presence of horizontal gene transfer (HGT) by allowing a diverse collection of code-sequence sets to compete with each other. We find that in the absence of horizontal gene transfer, natural selection between competing codes distinguished by differences in the degree of physico-chemical optimization is unable to explain the structure of the standard genetic code. However, for certain probabilities of the horizontal transfer events, a universal code emerges having a structure that is consistent with the standard genetic code.
Starting Page	287
Ending Page	291
Page Count	5
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	44
Issue Number	4
e-ISSN	15730875
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-01-15
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Origin Genetic code Natural selection Horizontal gene transfer Finite population Life Sciences Astrophysics and Astroparticles Earth Sciences Astronomy, Observations and Techniques Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

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