NDLI: The Structure and Function of Myelin: From Inert Membrane to Perfusion Pump

Content Provider	Springer Nature Link
Author	Dyer, Charissa A.
Copyright Year	2002
Abstract	The goal of this overview is to propose a novel structure/function model of central nervous system myelin. Although myelin is known to be a compact multilamellar structure that wraps around axons, the biologic role this structure plays in the nervous system remains an enigma. One means of ascertaining myelin's biologic role is by analyzing its structure. The recent discovery of tight junctions in myelin may be the key that unlocks the mysterious black box of myelin structure/function. Tight junctions in other cell types are invariably adjacent to adherens junctions, with both of these junctional plaques playing critical roles in paracellular barrier function, i.e., adhesion of cell membranes, signal transduction, and fluid movement between cells via aqueous pores and channels. The application of current knowledge about junctional plaques to myelin is an original concept. This knowledge, taken together with evidence from studies of normal and pathologic myelin, supports the possibility that a primary function of junctional plaques in myelin is to perfuse the periaxonal space.
Starting Page	1279
Ending Page	1292
Page Count	14
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	27
Issue Number	11
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2002-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

White Matter Rafting––Membrane Microdomains in Myelin

Nfasc155H and MAG are Specifically Susceptible to Detergent Extraction in the Absence of the Myelin Sphingolipid Sulfatide

Summary of wenner-gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: From structure to function

Was the ASN a Myelin Society?

Molecular Interactions of the Major Myelin Glycosphingolipids and Myelin Basic Protein in Model Membranes

Myelin Structure and Composition in Zebrafish ( Neurochemical Research , Volume 32 , Issue 2 )

Myelin Structure and Composition in Zebrafish ( Neurochemical Research , Volume 32 , Issue 2 )

Myelin Biogenesis: Vesicle Transport in Oligodendrocytes

Turnover of Myelin Lipids in Aging Brain

The Structure and Function of Myelin: From Inert Membrane to Perfusion Pump

Similar Documents

White Matter Rafting––Membrane Microdomains in Myelin

Nfasc155H and MAG are Specifically Susceptible to Detergent Extraction in the Absence of the Myelin Sphingolipid Sulfatide

Summary of wenner-gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: From structure to function

Was the ASN a Myelin Society?

Molecular Interactions of the Major Myelin Glycosphingolipids and Myelin Basic Protein in Model Membranes

Myelin Structure and Composition in Zebrafish ( Neurochemical Research , Volume 32 , Issue 2 )

Myelin Structure and Composition in Zebrafish ( Neurochemical Research , Volume 32 , Issue 2 )

Myelin Biogenesis: Vesicle Transport in Oligodendrocytes

Turnover of Myelin Lipids in Aging Brain

The Structure and Function of Myelin: From Inert Membrane to Perfusion Pump