NDLI: Intracellular GABA-Activated In→Out Permeation of Chloride Across the Deiters' Neuron Membrane: Modulation by Phosphorylating Activities

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Intracellular GABA-Activated In→Out Permeation of Chloride Across the Deiters' Neuron Membrane: Modulation by Phosphorylating Activities

Neurochemical Research : Volume 24, Issue 7, July 1999

Neurochemical Research : Volume 24, Issue 6, June 1999

Neurochemical Research : Volume 24, Issue 5, May 1999

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Neurochemical Research : Volume 24, Issue 3, March 1999

Neurochemical Research : Volume 24, Issue 2, February 1999

Neurochemical Research : Volume 24, Issue 1, January 1999

Neurochemical Research : Volume 23

Neurochemical Research : Volume 22

Intracellular GABA-Activated In→Out Permeation of Chloride Across the Deiters' Neuron Membrane: Modulation by Phosphorylating Activities

Content Provider	Springer Nature Link
Author	Rapalli, M. V. Cupello, A. Hydén, H.
Copyright Year	1999
Abstract	The modulation of intracellular GABA activated $^{36}$Cl$^{−}$ in→out permeation across single Deiters' neuron membranes has been studied in a microchamber system. Addition of Mg$^{2+}$/ATP on the membrane cytoplasmic side reduces strongly the GABA effect as does ATP alone. However, the greatest inhibition of the GABA effect is given by the addition of Mg$^{2+}$ to the intracellular side buffer: a complete block of the stimulation by GABA of $^{36}$Cl$^{−}$ in→out permeation. This is interpreted as due to the presence in this case of a constant concentration of exogenous Mg$^{2+}$ acting together with endogenous ATP in the small cytoplasmic layer on the membrane inner side. The addition of ADP to Mg$^{2+}$/ATP increases the inhibitory effect of the latter. This is presumably due to an extra increase of ATP, locally under the membrane, due to phosphorylation of ADP by endogenous phosphocreatine. Overall, the data confirm that phosphorylating conditions impair the intracellular GABA action on $^{36}$Cl$^{−}$ in→out permeation.
Starting Page	1089
Ending Page	1092
Page Count	4
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	24
Issue Number	8
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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