NDLI: The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase, and NADH Dehydrogenase, in Different Brain Regions in Alzheimer's Disease

Please wait, while we are loading the content...

Heterogeneous Long Chain Acyl-CoA Synthetases Control Distribution of Individual Fatty Acids in Newly-Formed Glycerolipids of Neuronal Cells Undergoing Neurite Outgrowth

Regional Activities of Phospholipase C after Experimental Brain Injury in the Rat

Possible Mechanism of Interaction of GABAergic-Adenosinergic Systems in the Regulation of Theophylline-Induced Locomotor Activity Under Its Nontolerant and Tolerant Conditions

The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase, and NADH Dehydrogenase, in Different Brain Regions in Alzheimer's Disease

Exposure to 2500 Lux Increases Serum Melatonin in Venezuelan Equine Encephalomyelitis

Role of Glutamate Receptors and Glutamate Transporters in the Regulation of the Glutamate-Glutamine Cycle in the Awake Rat

Expression of GDNF and GDNFR-α mRNAs in Muscles of Patients with Motor Neuron Diseases

Neurotoxic Potential of Three Structural Analogs of β-N-oxalyl-α,β-Diaminopropanoic Acid (β-ODAP)

Abstracts of the Neirokhimija 1998

Neurochemical Research : Volume 24, Issue 5, May 1999

Neurochemical Research : Volume 24, Issue 4, April 1999

Neurochemical Research : Volume 24, Issue 3, March 1999

Neurochemical Research : Volume 24, Issue 2, February 1999

Neurochemical Research : Volume 24, Issue 1, January 1999

Neurochemical Research : Volume 23

Neurochemical Research : Volume 22

The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase, and NADH Dehydrogenase, in Different Brain Regions in Alzheimer's Disease

Content Provider	Springer Nature Link
Author	Aksev, Michael Y. Tucker, H. Michael Nair, Prakash Akseva, Marina V. Butterfield, D. Allan Estus, Steven Markesbery, William R.
Copyright Year	1999
Abstract	In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered proportion between CO II and CO IV mRNAs was observed in the AD brain. Changes of the proportion between CO II and CO IV transcripts may contribute to the kinetic perturbation of CO documented in AD. A coordinated decrease of ND4 and ND15 mRNAs was found in the AD hippocampus and inferior parietal lobule, but not in cerebellum. The decrease of ND4 gene expression may lead to the inhibition of normal ubiquinone oxidoreductase activity of ND. This study suggests that changes of the expression of mitochondrial and nuclear genes, encoding parts of ND and CO enzyme complexes, may contribute to alterations of oxidative metabolism in AD.
Starting Page	767
Ending Page	774
Page Count	8
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	24
Issue Number	6
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effect of Electroconvulsive Shock on Mitochondrial Respiratory Chain in Rat Brain

Regulation of Cytochrome c Oxidase and FoF1-ATPase Subunits Expression in Rat Brain During Aging

Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria

Amyloid-β-Peptide Reduces the Expression Level of Mitochondrial Cytochrome Oxidase Subunits

Low Activity and Poor Membrane Tethering for Rabbit Brain Cytochrome c Oxidase in Cholesterol-Copper Alzheimer's Model

Intense Exercise Induces Mitochondrial Dysfunction in Mice Brain

Mitochondrial Complex Enzyme Activities and Cytochrome c Expression Changes in Multiple Sclerosis

Non-Nucleoside Reverse Transcriptase Inhibitors Efavirenz and Nevirapine Inhibit Cytochrome C Oxidase in Mouse Brain Regions

Elevated mitochondrial RNA in a Chinese hamster mutant deficient in the mitochondrially encoded subunits of NADH dehydrogenase and cytochrome c oxidase.

The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase, and NADH Dehydrogenase, in Different Brain Regions in Alzheimer's Disease

Similar Documents

Effect of Electroconvulsive Shock on Mitochondrial Respiratory Chain in Rat Brain

Regulation of Cytochrome c Oxidase and FoF1-ATPase Subunits Expression in Rat Brain During Aging

Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria

Amyloid-β-Peptide Reduces the Expression Level of Mitochondrial Cytochrome Oxidase Subunits

Low Activity and Poor Membrane Tethering for Rabbit Brain Cytochrome c Oxidase in Cholesterol-Copper Alzheimer's Model

Intense Exercise Induces Mitochondrial Dysfunction in Mice Brain

Mitochondrial Complex Enzyme Activities and Cytochrome c Expression Changes in Multiple Sclerosis

Non-Nucleoside Reverse Transcriptase Inhibitors Efavirenz and Nevirapine Inhibit Cytochrome C Oxidase in Mouse Brain Regions

Elevated mitochondrial RNA in a Chinese hamster mutant deficient in the mitochondrially encoded subunits of NADH dehydrogenase and cytochrome c oxidase.

The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase, and NADH Dehydrogenase, in Different Brain Regions in Alzheimer's Disease