NDLI: Modulation of PARP-1 and PARP-2 Expression by L-carnosine and Trehalose After LPS and INFγ-Induced Oxidative Stress

Content Provider	Springer Nature Link
Author	Spina Purrello, Vittoria Giliberto, Salvatrice Barresi, Vincenza Nicoletti, Vincenzo G. Giuffrida Stella, Anna Maria Rizzarelli, Enrico
Copyright Year	2010
Abstract	Poly(ADP-ribose) polymerases (PARPs) play a crucial role in DNA damage surveillance through their nick sensor functions. Since PARPs’ over activation leads to an excessive consumption of NAD$^{+}$ and ATP depletion, these enzymes also are involved in the early events of programmed cell death as well as in necrosis. In order to verify the protective action of L-carnosine and trehalose against NO induced cell death, in the present study we examined their effects on the expression of PARP-1, PARP-2 and iNOS in primary rat astrocyte and oligodendrocyte cells, treated with lipopolysaccharide (LPS) and interferon gamma (INFγ), through semi-quantitative PCR and western analysis. To further characterize the molecular mechanisms underlying L-carnosine and trehalose action, we measured cell viability, nitrite production and LDH release. The data obtained clearly demonstrate that in the stress model employed L-carnosine and trehalose down regulate PARP-1 and PARP-2 expression in both cell phenotypes, thus suggesting their possible application in clinical trials.
Starting Page	2144
Ending Page	2153
Page Count	10
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	35
Issue Number	12
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2010-10-30
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Astrocytes Oligodendrocytes PARP iNOS L-Carnosine Trehalose Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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