NDLI: Reduced Beta-Catenin Expression in the Hippocampal CA1 Region Following Transient Cerebral Ischemia in the Gerbil

Content Provider	Springer Nature Link
Author	Cho, Jeong Hwi Yan, Bing Chun Lee, Young Joo Park, Joon Ha Ahn, Ji Hyeon Kim, In Hye Lee, Jae Chul Kim, Young Myeong Lee, Bonghee Cho, Jun Hwi Won, Moo Ho
Copyright Year	2013
Abstract	Beta-catenin, a transcription factor, plays a critical role in cell survival and degradation after stroke. In this study, we examined changes of expression in beta-catenin in the hippocampal CA1 region of the gerbil following 5 min of transient cerebral ischemia. We observed neuronal damage using cresyl violet staining, neuronal nuclei immunohistochemistry and Fluro-Jade B immunofluorescence. Four days after ischemia-reperfusion (I-R), most of pyramidal cells in the CA1 region were damaged. In addition, early damage in dendrites was detected 1 day after I-R by immunohistochemical staining for microtubule-associated protein 2 (MAP-2), and MAP-2 immunoreactivity was hardly detected in the CA1 region 4 days after I-R. We found that beta-catenin (a synapse-enriched cell adhesion molecule) was well expressed in dendrites before I-R. Its immunoreactivity was well colocalized with MAP-2. Chronological change of beta-catenin immunoreactivity was novelty in the present study. Twelve hours after I-R, its immunoreactivity was decreased in the stratum radiatum of the CA1 region, however, its immunoreactivity was increased 1 and 2 days after I-R, and decreased sharply 4 days after I-R. However, we did not find any change in beta-catenin immunoreactivity in the CA2 and CA3 region. In brief, we suggest that early change of beta-catenin expression in the stratum pyramidale of ischemic hippocampal CA1 region is associated with early dendrite damage following transient cerebral ischemia.
Starting Page	1045
Ending Page	1054
Page Count	10
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	38
Issue Number	5
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2013-03-16
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ischemia-reperfusion injury Dendrite damage Microtubule-associated protein 2 Synaptic plasticity Beta-catenin Neurosciences Neurochemistry Biochemistry Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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