NDLI: Expression of Transferrin Binding Protein in the Capillaries of the Brain in the Developing Chick Embryo

Content Provider	Springer Nature Link
Author	Kim, Dong Woon Lee, Ha Na Song, Ji Eun Jung, Kyung Jin Yang, Woo Mi Kwon, Kisang Jeon, Gye Sun Lee, Young Ho Chung, Chun Kee Cho, Sa Sun
Copyright Year	2008
Abstract	Transferrin-binding protein (TfBP) has been shown to be a novel protein, structurally related to the chicken heat shock protein 108. The physiological function of this protein, however, has not yet been established. Antiserum to TfBP selectively stains transferrin- and iron-rich oligodendrocytes and choroidal epithelium in the adult and embryonic chick brain, suggesting a role for this protein in transferrin and iron storage in these cells. In this study, we further demonstrate TfBP-immunoreactivity (IR) in the blood vessels of the embryonic chick central nervous system. A strong TfBP-IR was present in blood vessels from E6, declined from E10 and was absent by E18. Thus, the expression of the TfBP in the blood vessels precedes its expression in the oligodendrocytes. At the subcellular level, TfBP-IR was confined to the cytoplasm of capillary pericytes while the Tf-receptor IR was associated with the capillary endothelium of the brain. The up-regulated expression of TfBP, together with the Tf-receptor of the brain capillaries, suggests that pericytes may be associated with the high iron uptake required for the metabolic demands of the developing brain.
Starting Page	2288
Ending Page	2293
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	33
Issue Number	11
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2008-05-06
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pericyte Iron Transferrin Transferrin-binding protein (TfBP) Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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