NDLI: Perturbed Synaptosomal Calcium Homeostasis and Behavioral Deficits Following Carbofuran Exposure: Neuroprotection by N-Acetylcysteine

Please wait, while we are loading the content...

Cerebellar Granule Neurons are More Vulnerable to Transient Transport-Mediated Glutamate Release than to Glutamate Uptake Blockade. Correlation with Excitatory Amino Acids Levels

Tyrosine Nitration is a Novel Post-translational Modification Occurring on the Neural Intermediate Filament Protein Peripherin

Salsolinol, an Endogenous Neurotoxin, Activates JNK and NF-κB Signaling Pathways in Human Neuroblastoma Cells

Down-Regulation of Platelet-Activating Factor Receptor Gene Expression During Focal Reversible Cerebral Ischemia in Rats

Ventral Tegmental Transcriptome Response to Intermittent Nicotine Treatment and Withdrawal in BALB/cJ, C57BL/6ByJ, and Quasi-Congenic RQI Mice

Nicotine Inhibits bFGF-induced Neurite Outgrowth through Suppression of NO Synthesis in H19-7 Cells

Pyrroloquinoline Quinone is a Potent Neuroprotective Nutrient Against 6-Hydroxydopamine-Induced Neurotoxicity

Venlafaxine Modulates Depression-Induced Oxidative Stress in Brain and Medulla of Rat

Perturbed Synaptosomal Calcium Homeostasis and Behavioral Deficits Following Carbofuran Exposure: Neuroprotection by N-Acetylcysteine

Fulminant Hepatic Failure in Rats Induces Oxidative Stress Differentially in Cerebral Cortex, Cerebellum and Pons Medulla

Effects of Typical and Atypical Antipsychotic Drugs on Rat Brain Muscarinic Receptors

Neurochemical Research : Volume 32, Issue 2, February 2007

Neurochemical Research : Volume 32, Issue 1, January 2007

Neurochemical Research : Volume 31

Neurochemical Research : Volume 30

Neurochemical Research : Volume 29

Neurochemical Research : Volume 28

Neurochemical Research : Volume 27

Neurochemical Research : Volume 26

Neurochemical Research : Volume 25

Neurochemical Research : Volume 24

Neurochemical Research : Volume 23

Neurochemical Research : Volume 22

Perturbed Synaptosomal Calcium Homeostasis and Behavioral Deficits Following Carbofuran Exposure: Neuroprotection by N-Acetylcysteine

Content Provider	Springer Nature Link
Author	Kamboj, Amit Sandhir, Rajat
Copyright Year	2007
Abstract	The protective effects of N-acetylcysteine (NAC) on carbofuran-induced alterations in calcium homeostasis and neurobehavioral functions were investigated in rats. Rats were exposed to carbofuran at a dose of 1 mg/kg body weight, orally for a period of 28 days. A significant decrease in Ca$^{2+}$ATPase activity was observed following carbofuran exposure with a concomitant increase in K$^{+}$-induced $^{45}$Ca$^{2+ }$uptake through voltage operated calcium channels. This was accompanied with a marked accumulation of intracellular free calcium in synaptosomes. The increase in intracellular calcium levels were associated with an increased lipid peroxidation and decreased glutathione content in carbofuran exposed animals. NAC administration (200 mg/kg body weight, orally) to the carbofuran exposed animals had a beneficial effect on carbofuran-induced alterations in calcium homeostasis and resulted in repletion in glutathione levels and resulted in lowering the extent of lipid peroxidation. Marked impairment in the motor functions were seen following carbofuran exposure, which were evident by the significant decrease in the locomotor activity and reduction in the retention time of the rats on rotating rods. Cognitive deficits were also seen as indicated by the significant decrease in active and passive avoidance response. NAC treatment, on the other hand, protected the animals against carbofuran-induced neurobehavioral deficits. The results support the hypothesis that carbofuran exerts its toxic effects by disrupting calcium homeostasis, which may have serious consequences on neuronal functioning, and clearly show the potential beneficial effects of N-acetylcysteine on carbofuran induced alterations in synaptosomal calcium homeostasis.
Starting Page	507
Ending Page	516
Page Count	10
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	32
Issue Number	3
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2007-02-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Carbofuran N-acetylcysteine Ca$^{2+}$-ATPase Voltage operated calcium channels Intracellular Ca$^{2+}$ Brain Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Golli Myelin Basic Proteins Modulate Voltage-Operated Ca$^{++}$ Influx and Development in Cortical and Hippocampal Neurons

Quinolinate-induced Rat Striatal Excitotoxicity Impairs Endoplasmic Reticulum Ca$^{2+}$-ATPase Function

N-Acetylcysteine Ameliorates Carbofuraninduced Alterations in Lipid Composition and Activity of Membrane Bound Enzymes

Differential Contribution of L-, N-, and P/Q-type Calcium Channels to [Ca$^{2+}$]$_{i}$ Changes Evoked by Kainate in Hippocampal Neurons

Complex Actions of Ionomycin in Cultured Cerebellar Astrocytes Affecting Both Calcium-Induced Calcium Release and Store-Operated Calcium Entry

Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons

Susceptibility to calcium dysregulation during brain aging

The Physiological Function of Store-operated Calcium Entry

Neuroprotection Induced by N-acetylcysteine and Selenium Against Traumatic Brain Injury-Induced Apoptosis and Calcium Entry in Hippocampus of Rat

Perturbed Synaptosomal Calcium Homeostasis and Behavioral Deficits Following Carbofuran Exposure: Neuroprotection by N-Acetylcysteine

Similar Documents

Golli Myelin Basic Proteins Modulate Voltage-Operated Ca$^{++}$ Influx and Development in Cortical and Hippocampal Neurons

Quinolinate-induced Rat Striatal Excitotoxicity Impairs Endoplasmic Reticulum Ca$^{2+}$-ATPase Function

N-Acetylcysteine Ameliorates Carbofuraninduced Alterations in Lipid Composition and Activity of Membrane Bound Enzymes

Differential Contribution of L-, N-, and P/Q-type Calcium Channels to [Ca$^{2+}$]$_{i}$ Changes Evoked by Kainate in Hippocampal Neurons

Complex Actions of Ionomycin in Cultured Cerebellar Astrocytes Affecting Both Calcium-Induced Calcium Release and Store-Operated Calcium Entry

Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons

Susceptibility to calcium dysregulation during brain aging

The Physiological Function of Store-operated Calcium Entry

Neuroprotection Induced by N-acetylcysteine and Selenium Against Traumatic Brain Injury-Induced Apoptosis and Calcium Entry in Hippocampus of Rat

Perturbed Synaptosomal Calcium Homeostasis and Behavioral Deficits Following Carbofuran Exposure: Neuroprotection by N-Acetylcysteine