NDLI: Cyclosporine A Reduces Dendritic Outgrowth of Neuroblasts in the Subgranular Zone of the Dentate Gyrus in C57BL/6 Mice

Content Provider	Springer Nature Link
Author	Hwang, In Koo Yi, Sun Shin Shin, Jae Hoon Yoo, Ki Yeon Choi, Jung Hoon Lee, Choong Hyun Seong, Je Kyung Yoon, Yeo Sung Park, Jeong Ho Won, Moo Ho
Copyright Year	2009
Abstract	In the present study, we observed the effects of cyclosporine A (CsA), an efficient immunosuppressant, on cell proliferation and neuroblast differentiation in the subgranular zone of the dentate gyrus (SZDG) in normal C57BL/6 mice using Ki67 and doublecortin (DCX) immunohistochemical staining, respectively. At 8 weeks of age, vehicle (physiological saline) or CsA was daily administered (40 mg/kg, i.p.) for 1 week. Animals were sacrificed at 2 weeks after last administration. CsA treatment did not show any influences in neurons, astrocytes and microglia based on immunohistochemistry for its markers, respectively. However, in the CsA-treated group, Fluoro-Jade B, a marker for neurodegeneration, positive cells were found in the SZDG, not in the vehicle-treated group. In the vehicle-treated group, Ki67 immunoreactive ($^{+}$) nuclei were clustered in the SZDG, whereas in the CsA-treated group Ki67$^{+}$ nuclei were scattered in the SZDG, showing no difference in cell numbers. Numbers of DCX$^{+}$ neuroblasts with well-developed processes (tertiary dendrites) were much lower in the CsA-treated group than those in the vehicle-treated group; however, numbers of DCX$^{+}$ neuroblasts with secondary dendrites were similar in both the groups. These results suggest that CsA significantly reduces dendritic outgrowth and complexity from neuroblasts in the SZDG without any affecting in neurons, astrocytes and microglia in normal mice.
Starting Page	465
Ending Page	472
Page Count	8
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	35
Issue Number	3
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2009-10-25
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cyclosporine A Dentate gyrus Subgranular zone Neuroblasts Neurogenesis Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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