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Delayed Hypothermia Prevents Decreases in N-Acetylaspartate and Reduced Glutathione in the Cerebral Cortex of the Neonatal Pig Following Transient Hypoxia-Ischaemia

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Delayed Hypothermia Prevents Decreases in N-Acetylaspartate and Reduced Glutathione in the Cerebral Cortex of the Neonatal Pig Following Transient Hypoxia-Ischaemia

Content Provider	Springer Nature Link
Author	Brooks, Keith J. Hargreaves, Iain Bhakoo, Kishore Sellwood, Mark O'Brien, Francis one, Martina Sakata, Yasuko Cady, Ernest Wylezinska, Marzena Thornton, John Ordidge, Roger Nguyen, Quyen Clemence, Matthew Wyatt, John Bates, Timothy E.
Copyright Year	2002
Abstract	The effects of normothermia and delayed hypothermia on the levels of N-acetylaspartate (NAA), reduced glutathione (GSH) and the activities of mitochondrial complex I, II-III, IV and citrate synthase were measured in brain homogenates obtained from anaesthetized neonatal pigs following transient in vivo hypoxia-ischaemia. In the normothermic animals there was a significant decrease in complex I activity and in the levels of GSH and NAA when compared to the controls. Delayed hypothermia preserved NAA and GSH at control levels and enhanced the rate of complex II-III activity. There was correlation (R = 0.79) between GSH and NAA levels when data from all three experimental groups were analyzed. Citrate synthase activity was not significantly different in the three groups, indicating maintenance of mitochondrial integrity. These data suggest that delayed hypothermia affords protection of integrated mitochondrial function in the neonatal brain following transient hypoxia-ischaemia.
Starting Page	1599
Ending Page	1604
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	27
Issue Number	12
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2002-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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Delayed Hypothermia Prevents Decreases in N-Acetylaspartate and Reduced Glutathione in the Cerebral Cortex of the Neonatal Pig Following Transient Hypoxia-Ischaemia

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Delayed Hypothermia Prevents Decreases in N-Acetylaspartate and Reduced Glutathione in the Cerebral Cortex of the Neonatal Pig Following Transient Hypoxia-Ischaemia