NDLI: Acute Hypoxia Differentially Affects the NMDA Receptor NR1, NR2A and NR2B Subunit mRNA Levels in the Developing Chick Optic Tectum: Stage-Dependent Plasticity in the 2B

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Acute Hypoxia Differentially Affects the NMDA Receptor NR1, NR2A and NR2B Subunit mRNA Levels in the Developing Chick Optic Tectum: Stage-Dependent Plasticity in the 2B–2A Ratio

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Acute Hypoxia Differentially Affects the NMDA Receptor NR1, NR2A and NR2B Subunit mRNA Levels in the Developing Chick Optic Tectum: Stage-Dependent Plasticity in the 2B–2A Ratio

Content Provider	Springer Nature Link
Author	Vacotto, Marina Rapacioli, Melina Flores, Vladimir Fiszer de Plazas, Sara
Copyright Year	2010
Abstract	It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage of NR1+ neurons displayed the higher plasticity during development while the NR2A+ neurons the higher stability. Acute hypoxia increased the mean percentage of NR1+ and NR2B+ neurons at ED12 but only that of NR1+ neurons at ED18. Acute hypoxia increased the levels of expression of NR1 and NR2B mRNAs at ED12 without changes in the NR2A mRNA. During early stages there is a higher sensitivity to change the subunits mRNA levels under a hypoxic treatment. At ED12 acute hypoxia increased the probability of co-expression of the NR1–NR2A and NR1–NR2B subunits combinations, the level of NR1 and NR2B and the ratio NR2B/NR2A. These conditions facilitate the evolution towards apoptosis.
Starting Page	1609
Ending Page	1619
Page Count	11
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	35
Issue Number	10
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2010-07-02
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hypoxia NMDA receptor Excitatory amino acid neurotransmitters Development Visual system Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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Acute Hypoxia Differentially Affects the NMDA Receptor NR1, NR2A and NR2B Subunit mRNA Levels in the Developing Chick Optic Tectum: Stage-Dependent Plasticity in the 2B–2A Ratio

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Acute Hypoxia Differentially Affects the NMDA Receptor NR1, NR2A and NR2B Subunit mRNA Levels in the Developing Chick Optic Tectum: Stage-Dependent Plasticity in the 2B–2A Ratio