NDLI: Lysosomes and Brain Aging in Mammals

Content Provider	Springer Nature Link
Author	Lynch, Gary Bi, Xiaoning
Copyright Year	2003
Abstract	Hypotheses about the factors controlling the rate of brain aging are usually derived from 1) correlates of maximum life span across mammals or 2) investigations into the causes of age-related neuropathologies in humans. With regard to the former, the strong correlation between metabolic rate and longevity prompted a variety of free radical hypotheses of aging. There is also evidence that brain size affects life span independently of body metabolism rates. The second approach has led to a diverse array of pathogenic mechanisms and, importantly for the development of general hypotheses, the discovery of animal analogues. The present paper discusses the possibility that age-associated lysosomal dysfunction constitutes a generalized mammalian phenomenon that accounts for specific features of the aged human brain. Immunocytochemical studies using rats and dogs have identified lysosomal changes that begin early in adulthood and are most pronounced in brain areas known to be particularly vulnerable to age-related pathogenesis in humans. Experimentally induced lysosomal dysfunction in cultured brain slices from rats and mutant mice triggers a wide array of changes associated with the aged human brain, including meganeurites and intraneuronal tangles. Finally, there is evidence that at least some forms of proteolysis decrease with increasing brain size across the mammals. The above observations lead to the suggestion that the expansion of neuronal arborizations that occurred in conjunction with increases in brain size secondarily slowed both neuronal metabolism and protein turnover. These events could have served to reduce the rate at which lysosomes (and other organelles) fail.
Starting Page	1725
Ending Page	1734
Page Count	10
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	28
Issue Number	11
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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