NDLI: Mechanisms Underlying Domoic Acid–Induced Dopamine Release from Striatum: An in Vivo Microdialysis Study

Content Provider	Springer Nature Link
Author	Alfonso, M. Durán, R. Campos, F. Perez Vences, D. Faro, L. R. F. Arias, B.
Copyright Year	2003
Abstract	The brain microdialysis technique has been used to examine the in vivo effects of the neurotoxin domoic acid (an ionotropic glutamate receptor agonist) on dopamine (DA) release in the striatum of conscious and freely moving rats. Local application of domoic acid (500 μM) through the microdialysis probe produced an increase in striatal DA content (597 ± 96% with respect to basal levels). The release of DA induced by domoic acid was not attenuated in a Ca$^{+2}$-free medium (469 ± 59%) or after pretreatment with 10 mg/kg reserpine (533 ± 79%). Intrastriatal infusion of 1 μM tetrodotoxin (TTX) partially reduced the domoic acid–evoked DA release (278 ± 34%). Moreover, domoic acid perfusion had no effect on K$^{+}$-evoked DA release. The results suggest that domoic acid increases the striatal DA release according to a reserpine-independent, calcium-independent and partially TTX-insensitive mechanism, suggesting that these effects probably involve a nonexocytotic process. On the other hand, the inhibitor of DA uptake nomifensine (10 μM) reduced the domoic acid–evoked DA release (356 ± 59%), suggesting that a carrier-dependent mechanism could be involved in the effect of domoic acid on the striatal DA levels.
Starting Page	1487
Ending Page	1493
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	28
Issue Number	10
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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