NDLI: Distinct Responses of DREAM to Electroacupuncture Stimulation with Different Frequencies During Physiological and Inflammatory Conditions in Rats

Content Provider	Springer Nature Link
Author	Li, Yi Zhang, Ying Han, Ji Sheng Wang, Yun
Copyright Year	2008
Abstract	Our previous results indicated that dynorphin in the spinal dorsal horn mediates the analgesic effect of high frequency electroacupuncture stimulation (EAS). Here we report that the transcriptional repressor downstream regulatory element antagonist modulator (DREAM) of dynorphin precursor-preprodynorphin (PPD) may participate in this process. In normal rats, 100 Hz, but not 2 Hz EAS triggered the nuclear export and membrane translocation of DREAM concomitantly with the upregulation of PPD mRNA in the dorsal horn. In inflammatory rats, both 2 and 100 Hz EAS alleviated thermal and mechanical hypersensitivity and caused the nuclear export and membrane translocation of DREAM, but only 100 Hz EAS enhanced the mRNA level of PPD and DREAM. These results suggest the role of DREAM in the dorsal horn in the regulation of PPD gene expression by EAS is frequency dependent, and DREAM may exert different roles in different frequency EAS under physiological and inflammatory conditions.
Starting Page	2070
Ending Page	2077
Page Count	8
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	33
Issue Number	10
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2008-04-11
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	DREAM Preprodynorphin Electroacupuncture Frequency Spinal dorsal horn Inflammation Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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