NDLI: Effect of Radicicol Infusion on the Src Tyrosine Kinase Activity of Rat Hippocampus before and after Training in an Inhibitory Avoidance Task

Please wait, while we are loading the content...

Differential Expression of Cerebellar Metabotropic Glutamate Receptors mGLUR2/3 and mGLUR4a after the Administration of a Convulsant Drug and the Adenosine Analogue Cyclopentyladenosine

Angiogenic Expression Profile of Normal and Neurofibromin-Deficient Human Schwann Cells

Effect of Hyperoxia on Cortical Neuronal Nuclear Function and Programmed Cell Death Mechanisms

Effect of Radicicol Infusion on the Src Tyrosine Kinase Activity of Rat Hippocampus before and after Training in an Inhibitory Avoidance Task

Oxidative Stress in Rat Retina and Hippocampus after Chronic MDMA (‘ecstasy’) Administration

Erythropoietin in Cerebrospinal Fluid: Age-related Reference Values and Relevance in Neurological Disease

Oxidative Stress Alters Physiological and Morphological Neuronal Properties

Effect of Chronic Administration of Ethanol on the Regulation of Tyrosine Kinase Phosphorylation of the GABA$_{A}$ Receptor Subunits in the Rat Brain

Protective Effects of Lamotrigine, Aripiprazole and Escitalopram on Depression-induced Oxidative Stress in Rat Brain

Brain Iron Toxicity: Differential Responses of Astrocytes, Neurons, and Endothelial Cells ( Neurochemical Research , Volume 32 , Issue 7 )

NTPDase and 5′-nucleotidase Activities of Synaptosomes from Hippocampus of Rats Subjected to Hyperargininemia

ADAM23 Plays Multiple Roles in Neuronal Differentiation of P19 Embryonal Carcinoma cells

MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition

Apoptotic Mode of Cell Death in Substantia Nigra Following Intranigral Infusion of the Parkinsonian Neurotoxin, MPP$^{+}$ in Sprague-Dawley Rats: Cellular, Molecular and Ultrastructural Evidences

In Vitro Studies on the Putative Function of N-acetylaspartate as an Osmoregulator

Differential Expression of Apoptotic Proteins Following Hypoxia-induced CREB Phosphorylation in the Cerebral Cortex of Newborn Piglets

Synaptic Plasticity in the Hippocampus: Effects of Estrogen from the Gonads or Hippocampus?

Neurochemical Research : Volume 32, Issue 6, June 2007

Neurochemical Research : Volume 32, Issue 4-5, April 2007

Neurochemical Research : Volume 32, Issue 3, March 2007

Neurochemical Research : Volume 32, Issue 2, February 2007

Neurochemical Research : Volume 32, Issue 1, January 2007

Neurochemical Research : Volume 31

Neurochemical Research : Volume 30

Neurochemical Research : Volume 29

Neurochemical Research : Volume 28

Neurochemical Research : Volume 27

Neurochemical Research : Volume 26

Neurochemical Research : Volume 25

Neurochemical Research : Volume 24

Neurochemical Research : Volume 23

Neurochemical Research : Volume 22

Effect of Radicicol Infusion on the Src Tyrosine Kinase Activity of Rat Hippocampus before and after Training in an Inhibitory Avoidance Task

Content Provider	Springer Nature Link
Author	Pereira, Patrícia Vinadé, Elsa Rodrigues, Letícia David e Silva, Tiago L. Ardenghi, Patrícia Silva Brum, Lucimar Filot Gonçalves, Carlos Alberto Izquierdo, Iván
Copyright Year	2007
Abstract	The participation of protein serine/threonine kinases in memory formation and retrieval is well established. In contrast, relatively little is known on the role of protein tyrosine kinases (PTKs). Previous work showed that intra-hippocampal infusion of the Src-PTK inhibitor radicicol inhibits memory acquisition, consolidation, and retrieval of one-trial step-down inhibitory avoidance task. In this study, we investigated the possible interaction between levels of Src-PTK activity in hippocampus and memory acquisition, formation, and retrieval of this task. Radicicol (0.5 μg/ml) was infused into the CA1 region of the hippocampus of rats trained in a one-trial step-down inhibitory avoidance task. Radicicol infused 15 min before training decreased Src-PTK activity, as measured 0, 1.5, and 24 h after training, and impaired memory acquisition of the task. When given immediately after training, there was a decrease in Src-PTK activity 1.5 h, but not 0 or 24 h after training. This treatment depressed memory consolidation. Radicicol infused into CA1 10 min prior to retrieval testing inhibited hippocampal Src-PTK activity, as measured immediately after the test session. The results suggest that Src-PTKs participate in memory acquisition, consolidation, and retrieval processes, but the timing of the role of the enzyme is different in each case.
Starting Page	1150
Ending Page	1155
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	32
Issue Number	7
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2007-03-31
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Src tyrosine kinases Memory Hippocampus Radicicol Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

DARPP-32 Expression in Rat Brain After an Inhibitory Avoidance Task

Guanidinoacetate administration increases acetylcholinesterase activity in striatum of rats and impairs retention of an inhibitory avoidance task

B-50/GAP-43 Phosphorylation and PKC Activity are Increased in Rat Hippocampal Synaptosomal Membranes After an Inhibitory Avoidance Training

NMDA Receptors Mediate Consolidation of Contextual Memory in the Hippocampus after Context Preexposure

Developmental Lead Exposure and Two-Way Active Avoidance Training Alter the Distribution of Protein Kinase C Activity in the Rat Hippocampus

N-methyl-D-aspartate receptors mediate diphosphorylation of extracellular signal-regulated kinases through Src family tyrosine kinases and Ca$^{2+}$/calmodulin-dependent protein kinase II in rat hippocampus after cerebral ischemia

Involvement of Src Tyrosine Kinases (SFKs) and of Focal Adhesion Kinase (FAK) in the Injurious Mechanism in Rat Primary Neuronal Cultures Exposed to Chemical Ischemia

Avoidance memory requires CaMKII activity to persist after recall

Extracellular Interconversion of Nucleotides Reveals an Ecto-Adenylate Kinase Activity in the Rat Hippocampus

Effect of Radicicol Infusion on the Src Tyrosine Kinase Activity of Rat Hippocampus before and after Training in an Inhibitory Avoidance Task

Similar Documents

DARPP-32 Expression in Rat Brain After an Inhibitory Avoidance Task

Guanidinoacetate administration increases acetylcholinesterase activity in striatum of rats and impairs retention of an inhibitory avoidance task

B-50/GAP-43 Phosphorylation and PKC Activity are Increased in Rat Hippocampal Synaptosomal Membranes After an Inhibitory Avoidance Training

NMDA Receptors Mediate Consolidation of Contextual Memory in the Hippocampus after Context Preexposure

Developmental Lead Exposure and Two-Way Active Avoidance Training Alter the Distribution of Protein Kinase C Activity in the Rat Hippocampus

N-methyl-D-aspartate receptors mediate diphosphorylation of extracellular signal-regulated kinases through Src family tyrosine kinases and Ca$^{2+}$/calmodulin-dependent protein kinase II in rat hippocampus after cerebral ischemia

Involvement of Src Tyrosine Kinases (SFKs) and of Focal Adhesion Kinase (FAK) in the Injurious Mechanism in Rat Primary Neuronal Cultures Exposed to Chemical Ischemia

Avoidance memory requires CaMKII activity to persist after recall

Extracellular Interconversion of Nucleotides Reveals an Ecto-Adenylate Kinase Activity in the Rat Hippocampus

Effect of Radicicol Infusion on the Src Tyrosine Kinase Activity of Rat Hippocampus before and after Training in an Inhibitory Avoidance Task