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| Content Provider | Springer Nature Link |
|---|---|
| Author | Linke, Stephanie Goertz, Philipp Baader, Stephan L. Gieselmann, Volkmar Siebler, Mario Junghans, Ulrich Kappler, Joachim |
| Copyright Year | 2006 |
| Abstract | Cell death after stroke involves apoptotic, autophagocytic and necrotic mechanisms which may cause the release of cytosolic proteins to the extracellular space. Aldolase C (AldC) is the brain specific isoform of the glycolytic enzyme fructose-1,6-bisphosphate aldolase. According to its characteristic striped expression pattern in the adult cerebellum AldC is also termed zebrin II. Here, we demonstrate release of AldC into the cerebrospinal fluid (CSF) after stroke in vivo. Studies with cell cultures confirmed that AldC is released to the extracellular space after hypoxia. Moreover, addition of purified recombinant AldC to networks of cortical neurons plated on multielectrode arrays reversibly inhibited the spontaneous generation of action potentials at AldC concentrations which can be expected to occur after lesions of the human cerebral cortex. This mechanism could be relevant in the pathogenesis of the electrophysiological changes in the penumbra region after stroke. |
| Starting Page | 1297 |
| Ending Page | 1303 |
| Page Count | 7 |
| File Format | |
| ISSN | 03643190 |
| Journal | Neurochemical Research |
| Volume Number | 31 |
| Issue Number | 11 |
| e-ISSN | 15736903 |
| Language | English |
| Publisher | Kluwer Academic Publishers-Plenum Publishers |
| Publisher Date | 2006-10-20 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Aldolase C Zebrin II Stroke Penumbra Development Cell death Purkinje cells Neurology Biochemistry Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Cellular and Molecular Neuroscience |
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