NDLI: ApoE −491A/T Promoter Polymorphism is not an Independent Risk Factor, but Associated with the ε4 Allele in Hungarian Alzheimer’s Dementia Population

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ApoE −491A/T Promoter Polymorphism is not an Independent Risk Factor, but Associated with the ε4 Allele in Hungarian Alzheimer’s Dementia Population

Content Provider	Springer Nature Link
Author	Juhász, Anna Palotás, András Janka, Zoltán Rimanóczy, Ágnes Palotás, Miklós Bódi, Nikoletta Boda, Krisztina Zana, Marianna Vincze, Gábor Kálmán, Jás
Copyright Year	2005
Abstract	Apolipoprotein E gene (Apoε) has three common alleles (ε2, ε3, and ε4), of which ε4 has been shown to be associated with an increased risk for Alzheimer’s disease (AD). Possible additional genetic factors, like the −491A variant of ApoE promoter may modify the development of AD, independently of the ApoE allele status. The objective of this study was to investigate whether A/T allelic polymorphism at site−491 of the ApoE promoter is associated with AD in a Hungarian population. The genomic DNA isolated from peripheral blood lymphocytes of 52 late-onset AD and 53 control individuals was used as a template for the two examined polymorphisms and PCR assay was applied. The ε4 allele was significantly over-represented in the AD group (28%) as compared with the control population (7%). No significant differences have been found between the control and the AD populations regarding the occurrence of the promoter A allele frequencies (control: 77%, AD: 70%). However, the AA genotype was more frequent in the AD group (48%) than in the control (10%) when the presence of ε4 allele was also considered. It is unlikely therefore that the −491A variant of the ApoE promoter gene is an independent risk factor in the Hungarian AD population, but a linkage disequilibrium exists between the two examined mutations.
Starting Page	591
Ending Page	596
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	30
Issue Number	5
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2005-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Apolipoprotein E Alzheimer’s disease ApoE promoter Hungarian population genetic risk factor Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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ApoE −491A/T Promoter Polymorphism is not an Independent Risk Factor, but Associated with the ε4 Allele in Hungarian Alzheimer’s Dementia Population

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ApoE −491A/T Promoter Polymorphism is not an Independent Risk Factor, but Associated with the ε4 Allele in Hungarian Alzheimer’s Dementia Population