NDLI: Effects per se of Organic Solvents in the Cerebral Acetylcholinesterase of Rats

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Effects per se of Organic Solvents in the Cerebral Acetylcholinesterase of Rats

Content Provider	Springer Nature Link
Author	Obregon, Adriana D.C. Schetinger, Maria R. C. Correa, Maísa M. Morsch, Vera M. Silva, José E.P. da Martins, Marcos A. P. Bonacorso, Hélio G. Zanatta, Nilo
Copyright Year	2005
Abstract	Acetylcholinesterase (AChE) was studied in different rat brain regions (cerebellum, hypothalamus, striatum, hippocampus and cortex) in the presence of different organic solvents normally used in the in vitro assay. The organic solvents used were acetone (C$_{3}$H$_{6}$O), acetonitrile (C$_{2}$H$_{3}$N), ethyl alcohol (C$_{2}$H$_{6}$O), isopropyl alcohol (C$_{3}$H$_{8}$O), methyl alcohol (CH$_{4}$O), tert-butyl alcohol (C$_{4}$H$_{10}$O) and dimethyl sulfoxide (DMSO, C$_{2}$H$_{6}$OS) ranging from 0.6 to 10%. Ethyl and methyl alcohol presented no effect on AChE activity at any of the concentrations and brain structures tested. In the hippocampus, isopropyl alcohol did not demonstrate a significant inhibitory effect, even at high concentrations. Tert-butyl alcohol presented an interesting result, increased AChE activity (P < .05) in the hypothalamus (1.8%), cortex (1.8 and 2.5) and striatum (1.2, 1.8 and 2.5%) and decreased activity at a concentration of 10% in the cortex (P < .05) and striatum (P < .01). Acetone and acetonitrile presented similar results, both significantly inhibiting AChE in all structures (5%, P < .05 and 10%, P < .01). DMSO exhibited a highly inhibitory effect at practically all concentrations tested (P < .01). In conclusion, for testing new compounds on AChE activity in vitro, methyl and ethyl alcohol may be the best organic solvent choice.
Starting Page	379
Ending Page	384
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	30
Issue Number	3
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2005-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	AChE organic solvents brain Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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