NDLI: Free Radical Generation by Neurons in Rat Model of Japanese Encephalitis

Content Provider	Springer Nature Link
Author	Srivastava, Ruchi Kalita, Jayantee Khan, Mohammad Yahiya Misra, Usha Kant
Copyright Year	2009
Abstract	Increased generation of free radicals resulting in brain injury is a feature of many viral infections. The present study has been undertaken to evaluate the level of free radicals in Japanese encephalitis. Twelve days old Wistar rats were inoculated intracerebrally with 3 × 10$^{6}$ pfu of JE virus and were sacrificed on 3, 6, 10, and 20 days post inoculation (dpi). The neuronal levels of reactive oxygen species (ROS), nitric oxide (NO), peroxinitrite (OONO$^{−}$), necrotic and apoptotic cell population were estimated by flow cytometry. Hematoxylin-eosin staining was also performed. Maximum level of neuronal ROS and OONO$^{−}$ was observed on 6 dpi; however, NO levels peaked on 10 dpi. Free radical generation significantly declined on 20 dpi as compared to control. Apoptotic cell death gradually increased over the time. Neuronal shrinkage and necrosis was also observed. The results of our study indicate that free radicals increased in acute JE and declined at later stage, which may contribute to cell death.
Starting Page	2141
Ending Page	2146
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	34
Issue Number	12
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2009-06-03
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Japanese encephalitis Rat model Free radical generation Cell injury Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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