NDLI: The Expression of NMDA Receptor Subunits in Cerebral Cortex and Hippocampus is Differentially Increased by Administration of Endobain E, a Na$^{+}$, K$^{+}$-ATPase Inhibitor

Content Provider	Springer Nature Link
Author	Bersier, María Geraldina Peña, Clara Rodríguez de Lores Arnaiz, Georgina
Copyright Year	2007
Abstract	Previous studies showed that endobain E, an endogenous Na$^{+}$, K$^{+}$-ATPase inhibitor, decreases dizocilpine binding to NMDA receptor in isolated membranes. The effect of endobain E on expression of NMDA receptor subunits in membranes of rat cerebral cortex and hippocampus was analyzed by Western blot. Two days after administration of 10 μl endobain E (1 μl = 29 mg fresh tissue) NR1 subunit expression enhanced 5-fold and 2.5-fold in cerebral cortex and hippocampus, respectively. NR2A subunit expression increased 2-fold in cerebral cortex and 1.5-fold in hippocampus. The level of NR2B subunit raised 3-fold in cerebral cortex but remained unaltered in hippocampus. NR2C subunit expression was unaffected in either area. NR2D subunit enhanced 1.6 and 2.1-fold for cerebral cortex and hippocampus, respectively. Results indicate that endogenous Na$^{+}$, K$^{+}$-ATPase inhibitor endobain E differentially modifies the expression of NMDA receptor subunits.
Starting Page	66
Ending Page	72
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	33
Issue Number	1
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2007-08-08
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	NMDA receptor subunits Na$^{+}$, K$^{+}$-ATPase inhibitor Cerebral cortex Hippocampus Endobain E Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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