NDLI: Effect of In Vivo Administration of Naloxone on ATP-ase's Enzyme Systems of Synaptic Plasma Membranes from Rat Cerebral Cortex

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Effect of In Vivo Administration of Naloxone on ATP-ase's Enzyme Systems of Synaptic Plasma Membranes from Rat Cerebral Cortex

Content Provider	Springer Nature Link
Author	Gorini, A. Rancati, A. D'Angelo, A. Devecchi, E. Villa, R. F.
Copyright Year	2000
Abstract	Naloxone is a specific competitive antagonist of morphine, acting on opiate receptors, located on neuronal membranes. The effects of in vivo administration of naloxone on energy-consuming non-mitochondrial ATP-ases were studied in two different types of synaptic plasma membranes from rat cerebral cortex, known to contain a high density of opiate receptors. The enzyme activities of Na$^{+}$, K$^{+}$-ATP-ase, Ca$^{2+}$, Mg$^{2+}$-ATP-ase and Mg$^{2+}$-ATP-ase and of acetylcholinesterase (AChE) were evaluated on synaptic plasma membranes obtained from control and treated animals with effective dose of naloxone (12μg · kg$^{−1}$ i.m. 30 minutes). In control (vehicle-treated) animals specific enzyme activities assayed on these two types of synaptic plasma membranes are different, being higher on synaptic plasma membranes of II type than of I type, because the first fraction is more enriched in synaptic plasma membranes. The acute treatment with naloxone produced a significant decrease in Ca$^{2+}$,Mg$^{2+}$-ATP-ase activity and an increase in AChE activity, only in synaptic plasma membranes of II type. The decrease of Ca$^{2+}$,Mg$^{2+}$-ATP-ase enzymatic activity and the increased AChE activity are related to the interference of the drug on Ca$^{2+}$ homeostasis in synaptosoplasm, that leads to the activation of calcium-dependent processes, i.e. the extrusion of neurotransmitter. These findings give further evidence that pharmacodynamic characteristics of naloxone are also related to increase [Ca$^{2+}$]$_{ i }$, interfering with enzyme systems (Ca$^{2+}$,Mg$^{2+}$-ATP-ase) and that this drug increases acetylcholine catabolism in synaptic plasma membranes of cerebral cortex.
Starting Page	867
Ending Page	873
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	25
Issue Number	6
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2000-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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