NDLI: Salviae Miltiorrhizae BGE Radix Increases Rat Striatal K$^{+}$-Stimulated Dopamine Release and Activates the Dopamine Release with Protection Against Hydrogen Peroxide-Induced Injury in Rat Pheochromocytoma PC12 Cells

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Salviae Miltiorrhizae BGE Radix Increases Rat Striatal K$^{+}$-Stimulated Dopamine Release and Activates the Dopamine Release with Protection Against Hydrogen Peroxide-Induced Injury in Rat Pheochromocytoma PC12 Cells

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Salviae Miltiorrhizae BGE Radix Increases Rat Striatal K$^{+}$-Stimulated Dopamine Release and Activates the Dopamine Release with Protection Against Hydrogen Peroxide-Induced Injury in Rat Pheochromocytoma PC12 Cells

Content Provider	Springer Nature Link
Author	Chung, Tae Wook Koo, Byung Soo Kim, Kyeong Oh Jeong, Hee Sang Kim, Min Gon Chung, Kang Hung Lee, In Seon Kim, Cheorl Ho
Copyright Year	2006
Abstract	The present study investigated the effect of the medicinal plant Salviae miltiorrhizae radix (SMR) on dopaminergic neurotransmission in comparison with amphetamine. The effect of SM (0.1 g/ml) on K$^{+}$ (20 mM)-stimulated dopamine (DA) release from rat striatal slices was compared with amphetamine (10$^{−4}$ M). Amphetamine and SMR significantly increased K$^{+}$-stimulated DA release (P<0.001) from rat striatal slices when compared with K$^{+}$-stimulated alone. On the other hand, to examine whether in vitro SMR treatment induces DA release in PC12 cells, the role of protein kinases has been investigated in the induction of the SMR-mediated events by using inhibitors of protein kinase C (PKC), mitogen activated protein kinase (MAP kinase) or protein kinase A (PKA). PKC inhibitors chelerythrine (50 and 100 nM), Ro31-8220 (100 nM) and the MAP kinase inhibitor, PD98059 (20 μM) inhibited the ability of SMR to elicit the SMR-stimulated DA release. The direct-acting PKC activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA, 100 nM) mimicked the ability of SMR to elicit DA release. On the contrary, a selective PKA inhibitor, 50 μM Rp-8-Br-cAMP, blocked the development of SMR-stimulated DA release. The results demonstrated that SMR may stimulate DA release and that SMR-induced increases in MAP kinase and PKC are important for induction of the enhancement in transporter-mediated DA release and PKA was also required for the enhancement in SMR-stimulated DA release. SMR treatment (0.1–10 μg/ml) to the hydrogen peroxide (H$_{2}$O$_{2}$)-treated PC12 cells activated the enzyme activities such as catalase, superoxide dismutase and glutathione peroxidase, and decreased the malondialdehyde level, indicating that SMR has also protective effects against free radical-induced cell toxicity. Therefore, the mechanism by which SMR induces the enhancement in SMR-stimulated DA release is apparent. It remains to be determined whether the effect of SMR on DA function is important in its therapeutic use in the treatment of drug addiction.
Starting Page	109
Ending Page	120
Page Count	12
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	31
Issue Number	1
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Salviae miltiorrhizae radix dopamine amphetamine PKC MAP kinase PKA free radicals hydrogen peroxide glutathione peroxidase catalase superoxide dismutase PC12 cells malondialdehyde Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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Salviae miltiorrhizae Radix Inhibits Superoxide Generation by Activated Rat Microglias and Mimics the Action of Amphetamine on in vitro Rat Striatal Dopamine Release

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Salviae Miltiorrhizae BGE Radix Increases Rat Striatal K$^{+}$-Stimulated Dopamine Release and Activates the Dopamine Release with Protection Against Hydrogen Peroxide-Induced Injury in Rat Pheochromocytoma PC12 Cells

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Salviae Miltiorrhizae BGE Radix Increases Rat Striatal K$^{+}$-Stimulated Dopamine Release and Activates the Dopamine Release with Protection Against Hydrogen Peroxide-Induced Injury in Rat Pheochromocytoma PC12 Cells