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Neuroprotective potential of epigallo catechin-3-gallate in PC-12 cells

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Neuroprotective potential of epigallo catechin-3-gallate in PC-12 cells

Content Provider	Springer Nature Link
Author	Srividhya, Ravichandran Kalaiselvi, Periandavan
Copyright Year	2012
Abstract	Oxidative stress is a major player in aging and neurodegenerative disorders. Macromolecular damage occurs as a result of oxidative stress that affects the mitochondria. Mitochondrial damage leads to cell death by apoptosis or necrosis. EGCG is a tea polyphenol that protects the cells against oxidative stress. Neuroprotective potential of EGCG was tested against H$_{2}$O$_{2}$ induced oxidative stress in PC-12 cells. PC-12 cells were grown in tissue culture flasks. Oxidative stress was induced by adding H$_{2}$O$_{2}$ to the cells. EGCG was also added and the cell death was assessed using MTT assay. Oxidative stress was assessed by protein carbonyl and thiol status. Mitochondrial membrane potential was studied using JC-1 staining. TNF-α levels were assessed using ELISA. H$_{2}$O$_{2}$ increased the protein carbonyl content and reduced the thiol status in the PC-12 cells. Cell death was increased in H$_{2}$O$_{2}$ treated cells as shown by MTT assay. Mitochondrial membrane potential was also decreased along with increase in TNF-α level in H$_{2}$O$_{2}$ treated cells. EGCG brought about an increase in the cellular thiol status and decreased the protein carbonyl content in the PC-12 cells. Cell death was attenuated by EGCG treatment along with an increase in mitochondrial membrane potential and decrease in TNF-α level. EGCG conferred its antioxidant potential to PC-12 cells as evident by decreased protein damage. Mitochondrial membrane potential was improved along with a decrement in the cell death in PC-12 cells. EGCG acts as a good neutraceutical antioxidant to render neuroprotectivity to PC-12 cells.
Starting Page	486
Ending Page	493
Page Count	8
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	38
Issue Number	3
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2012-12-02
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	EGCG PC-12 cells Mitochondrial membrane potential H$_{2}$O$_{2}$ Neuroprotection Oxidative stress Neurosciences Neurochemistry Biochemistry Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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