NDLI: Effect of Hypoxia and Dopamine on Arachidonic Acid Metabolism in Superior Cervical Ganglion

Content Provider	Springer Nature Link
Author	Strosznajder, Robert Piotr
Copyright Year	1997
Abstract	Superior cervical ganglion (SCG) may play a modulatory role on ventilatory control through its efferent sympathetic fibres, which innervate cells in the carotid bodies. In this study the in vivo effect of acute hypoxia versus normoxia on arachidonic acid (AA) metabolism was investigated in cat SCG. Using SCG homogenate AA was incorporated into glycerolipids of normoxic SCG in the following order: neutral glycerolipids > phosphatidylcholine (PtdCh) > phosphatidylinositol (PtdIns) > phosphatidylethanolamine (PtdE) > phosphatidylserine (PtdS) > and phosphatidic acid (PA). In vivo hypoxic treatment caused a significant decrease in incorporation of [1-$^{14}$C]AA into PtdIns. Hypoxia had no significant effect on the level of AA radioactivity in diacylglycerol (DAG) as compared to control but significantly enhanced the level of arachidonoyl-CoA (AA-CoA) radioactivity. It was observed that dopamine (DA) one of the most important neurotransmitter in SCG decreases AA uptake into phospholipids of normoxic SCG. In normoxic SCG, DA significantly decreased, AA incorporation into PtdCh, PtdIns and DAG. Moreover, DA decreased the level of AA-CoA radioactivity. Hypoxia and dopamine has no effect on AA metabolism in medulla oblongata isolated from the same animals. These results indicate that arachidonic acid metabolism in SCG is sensitive to hypoxia and dopamine action. Moreover, these results indicate that hypoxia inhibits selectively AA incorporation on the level of acylCoA-lysophosphatidylinositol-acyltransferase.
Starting Page	1193
Ending Page	1197
Page Count	5
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	22
Issue Number	10
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1997-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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