NDLI: Interleukin-1β (187–207)-Induced Hyperthermia is Inhibited by Interleukin-1β (193

Content Provider	Springer Nature Link
Author	Palotai, Miklós Kiss, Edina Bagosi, Zsolt Jászberényi, Miklós Tóth, Gábor Váradi, Györgyi Telegdy, Gyula
Copyright Year	2013
Abstract	Interleukin-1β (IL-1β) is a pro-inflammatory cytokine, which plays an important role in the immune response and signal transduction both in the periphery and the central nervous system (CNS). Various diseases of the CNS, including neurodegenerative disorders, vascular lesions, meningo-encephalitis or status epilepticus are accompanied by elevated levels of IL-1β. Different domains within the IL-lβ protein are responsible for distinct functions. The IL-lβ domain in position 208–240 has pyrogenic properties, while the domain in position 193–195 exerts anti-inflammatory effects. Previous studies provide little evidence about the effect of the domain in position 187–207 on the body temperature. Therefore, the aim of the present study was to investigate the action of IL-1β (187–207) and its interaction with IL-1β (193–195) on the body temperature. IL fragments were administered intracerebroventricularly and the body temperature was measured rectally in male Wistar rats. IL-1β (187–207) induced hyperthermia, while IL-1β (193–195) did not influence the core temperature considerably. In co-administration, IL-1β (193–195) completely abolished the IL-1β (187–207)-induced hyperthermia. The non-steroid anti-inflammatory drug metamizole also reversed completely the action of IL-1β (187–207). Our results provide evidence that the IL-lβ domain in position 187–207 has hyperthermic effect. This effect is mediated through prostaglandin E2 stimulation and other mechanisms may also be involved in the action of IL-1β (187–207). It also suggests that IL-lβ domain in position 187–207 and IL-1β (193–195) fragment may serve as novel target for treatment of disorders accompanied with hyperthermia.
Starting Page	254
Ending Page	258
Page Count	5
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	39
Issue Number	2
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2013-12-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	IL-1β (187–207) IL-1β (193–195) Metamizole Hyperthermia Neurosciences Neurochemistry Biochemistry Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Neuroprotective Peptide Humanin Inhibits Inflammatory Response in Astrocytes Induced by Lipopolysaccharide

Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes

IL-10 and IL-1β Mediate Neuropathic-Pain Like Behavior in the Ventrolateral Orbital Cortex

Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC)

Curcumin Attenuates CFA Induced Thermal Hyperalgesia by Modulation of Antioxidant Enzymes and Down Regulation of TNF-α, IL-1β and IL-6

TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH

Acute Cocaine Increases Interleukin-1β mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens

Interleukin-1β Inhibits Voltage-Gated Sodium Currents in a Time- and Dose-Dependent Manner in Cortical Neurons

Interleukin-1β (187–207)-Induced Hyperthermia is Inhibited by Interleukin-1β (193–195) in Rats

Similar Documents

Neuroprotective Peptide Humanin Inhibits Inflammatory Response in Astrocytes Induced by Lipopolysaccharide

Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes

IL-10 and IL-1β Mediate Neuropathic-Pain Like Behavior in the Ventrolateral Orbital Cortex

Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC)

Curcumin Attenuates CFA Induced Thermal Hyperalgesia by Modulation of Antioxidant Enzymes and Down Regulation of TNF-α, IL-1β and IL-6

TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH

Acute Cocaine Increases Interleukin-1β mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens

Interleukin-1β Inhibits Voltage-Gated Sodium Currents in a Time- and Dose-Dependent Manner in Cortical Neurons

Interleukin-1β (187–207)-Induced Hyperthermia is Inhibited by Interleukin-1β (193–195) in Rats