NDLI: Dynamic Reduction of Plasma Decorin Following Ischemic Stroke: A Pilot Study

Content Provider	Springer Nature Link
Author	Xu, Yuan Zhi Yang, Zhi Gang Zhang, Yu Hui Zhang, Yong Wei Hong, Bo Liu, Jian Min
Copyright Year	2012
Abstract	The aim of this study was to investigate the dynamic changes in plasma decorin concentration after acute ischemic stroke and to study its relationship with clinical stroke subtypes. We collected three plasma samples from patients with acute ischemic stroke (n = 35) and controls (n = 30): upon admission (1–3 days) between 3 days and 1 week (3–7 days), and between 7 days and 2 weeks (7–14 days). The relationship between Decorin concentration and Trial of ORG10172 in Acute Stroke Treatment (TOAST) subtypes and outcomes were evaluated. The concentration of decorin gradually decreased following the onset of stroke at all different time-points (<3 days, p < 0.05; 3–7 days, p < 0.01; and 7–14 days, p < 0.01) compared to controls. The level of decorin at 7–14 days is significantly lower than that at <3 days (p < 0.01) in the stroke patients. Decorin levels were lower in the Large-artery atherosclerosis group than the rest of the TOAST subgroups (p = 0.024). Decorin levels decreased more in the patients with poor outcome (mRS 3–6) than those with favorable outcome (mRS 0–2, p < 0.05) at a time-point of 3–7 days. There is a dynamic reduction in Decorin level the days following ischemic stroke, and the decrement persists at least the first 2 weeks. The dynamic reduction of decorin might indicate that decorin is concomitantly involved in the pathophysiological processes of stroke. Larger studies are needed to confirm whether decorin is a useful marker of stroke and a prognostic indicator of outcome.
Starting Page	1843
Ending Page	1848
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	37
Issue Number	9
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2012-06-08
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Decorin Stroke Atherosclerosis Extracellular matrix remodeling Biochemistry Cell Biology Neurology Neurochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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