NDLI: A Neuron Model Including Gene Expression: Bistability, Long-Term Memory, etc.

Content Provider	Springer Nature Link
Author	Zhdav, Vladimir P.
Copyright Year	2013
Abstract	Acquisition, consolidation and reconsolidation of long-term memories include changes in gene expression in neurons. The understanding of the corresponding mechanistic details is still far from complete even on the conceptual level. Here, the author proposes a generic kinetic model describing a global interplay between the function of membrane ion channels and gene expression, including gene transcription into mRNA and mRNA translation into protein. The model, based partly on the Hindmarsh–Rose neuron model for membrane voltage, implies feedbacks between these processes. Specifically, the gene transcription is considered to depend on membrane voltage due to the corresponding dependence of one of the transcription factors. The number or efficiency of function of ion channels is in turn assumed to depend on the protein population. With these feedbacks, the model predicts either a single steady state or bistability. The bistable regimes are briefly discussed in the context of long-term memory.
Starting Page	285
Ending Page	296
Page Count	12
File Format	PDF
ISSN	13704621
Journal	Neural Processing Letters
Volume Number	39
Issue Number	3
e-ISSN	1573773X
Language	English
Publisher	Springer US
Publisher Date	2013-05-18
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Theoretical neuroscience Membrane-potential spikes Subcellular processes Mean-field kinetic equations Artificial Intelligence (incl. Robotics) Statistical Physics, Dynamical Systems and Complexity Computational Intelligence
Content Type	Text
Resource Type	Article
Subject	Neuroscience Artificial Intelligence Computer Networks and Communications Software

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