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| Content Provider | Springer Nature Link |
|---|---|
| Author | Bahrami, F. Hashemi, M. Khalili, F. Hashemi, J. Asgari, A. |
| Copyright Year | 2013 |
| Abstract | Cannabinoids have been shown to exert a neuroprotective influence in organophosphorus-induced toxicity. In our study, we examined the effects of the cannabinoid receptor agonist WIN55,212-2 and NMDA receptor agonist NMDA on cell death in the pheochromocytoma cell line PC12 subjected to the action of an organophosphorus compound, diazinon. Diazinon decreased cell viability in a concentration-dependent manner. Following the exposure of PC12 cells to 200 μM diazinon for 48 h, reductions in cell survival and protein level of CB1 receptors were observed. Treatment of the cells with 0.1 μM WIN55,212-2 and 100 μM NMDA prior to diazinon exposure significantly elevated the cell survival level and protein level of CB1 receptors. The cannabinoid antagonist AM251 (1 μM) did not inhibit the neuroprotection effect induced by WIN55,212-2, indicating that the neuroprotective effect of this agonist was cannabinoid receptor-independent. The NMDA receptor antagonist MK-801 (1 μM) enhanced diazinon-mediated neurotoxicity suggesting that precisely NMDA receptors may play a protective role. |
| Starting Page | 433 |
| Ending Page | 440 |
| Page Count | 8 |
| File Format | |
| ISSN | 00902977 |
| Journal | Neurophysiology |
| Volume Number | 45 |
| Issue Number | 5-6 |
| e-ISSN | 15739007 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-12-18 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | cannabinoids diazinon neuroprotection neurotoxicity PC12 cells viability Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Physiology |
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