NDLI: Regulation of S100B Expression in Long-Term Potentiation

Content Provider	Springer Nature Link
Author	Lisachev, P. D. Pustyl’nyak, V. O. Shtark, M. B.
Copyright Year	2016
Abstract	The role of intracellular regulatory cascades in inducing the expression of S100B during the formation of long-term post-tetanic potentiation (LTP) in field CA1 was studied in hippocampal slices from rats. Activation of transcription factor p53 (a positive regulator of S100B transcription) using nutlin-3 increased the basal level of S100B mRNA to 151% of control, which was significantly lower than its content in tetanized slices (280%). Thus, p53 cannot be the only transcription factor regulating S100B expression in LTP. KN-93, an inhibitor of Ca$^{2+}$/calmodulin-dependent kinases (CaMK), completely blocked the increase in the S100B mRNA level after tetanization, while its inactive analog KN-92 had no effect on S100B expression. K-252a, an inhibitor of CaMKII and receptor tyrosine kinases, significantly suppressed S100B expression in LTP, while inhibition of MAPK p38 or RSK2 produced moderate decreases and inhibition of MEK1 had no effect on the quantity of S100B mRNA. Thus, calmodulin kinases play a key role in inducing S100B expression in LTP.
Starting Page	312
Ending Page	318
Page Count	7
File Format	PDF
ISSN	00970549
Journal	Neuroscience and Behavioral Physiology
Volume Number	46
Issue Number	3
e-ISSN	1573899X
Language	English
Publisher	Springer US
Publisher Date	2016-01-25
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	long-term potentiation hippocampal slices CA1 S100B p53 Ca$^{2+}$/calmodulin-dependent kinases Neurosciences Neurobiology Behavioral Sciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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