NDLI: Neurodegenerative Changes in Rat Hippocampal Fields during the Development of Pentylenetetrazole Kindling

Content Provider	Springer Nature Link
Author	Popova, M. S. Aniol, V. A. Lazareva, N. A. Stepanichev, M. Yu. Gulyaeva, N. V.
Copyright Year	2013
Abstract	The development of pentylenetetrazole kindling is accompanied by neuron degeneration and death in different hippocampal fields. Nonetheless, data on the development of neurodegenerative processes in the dentate gyrus (DG) remain contradictory. The study reported here, performed on 20 male Wistar rats, established that the extent of neuron death varied in different zones of the DG. By the end of the development of pentylenetetrazole kindling, the superior and inferior blades of the DG showed cell degeneration, though the number of neurons did not decrease; at the angle of the DG, there was a decrease in the number of neurons from the early stages of kindling. This provides grounds for suggesting the existence of functional heterogeneity in the granule neuron population in terms of sensitivity to the harmful actions of convulsions.
Starting Page	592
Ending Page	596
Page Count	5
File Format	PDF
ISSN	00970549
Journal	Neuroscience and Behavioral Physiology
Volume Number	43
Issue Number	5
e-ISSN	1573899X
Language	English
Publisher	Springer US
Publisher Date	2013-06-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	hippocampus dentate gyrus pentylenetetrazole kindling neuron death Neurosciences Neurobiology Behavioural Sciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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Neurodegenerative Changes in Rat Hippocampal Fields during the Development of Pentylenetetrazole Kindling