NDLI: Neuroimmune Aspects of the Pathogenesis of Tourette’s Syndrome and Experience in the Use of Immunoglobulins in Children

Content Provider	Springer Nature Link
Author	Zykov, V. P. Shcherbina, A. Yu. vikova, E. B. Shvabrina, T. V.
Copyright Year	2009
Abstract	A total of 60 patients aged 6–16 years with tics and Tourette’s syndrome were studied. Antibodies to caudate nucleus proteins were assayed by western blot hybridization. Ten patients with Tourette’s syndrome were found to have antibodies to caudate nucleus protein. Seven patients with neuroleptic-resistant types of Tourette’s syndrome received single transfusions of immunoglobulin preparations, which produced regression of vocal and motor hyperkinesias and improvement in behavior (remission for more than six months). The observation of antibodies to caudate nucleus proteins and the positive effects seen on administration of immunoglobulins to patients with Tourette’s syndrome support previous data on the possibility of using immunoglobulin therapy in the treatment of tic-type hyperkinesias and provide evidence of the involvement of autoimmune mechanisms inducing damage to the dopaminergic system of the striatum.
Starting Page	635
Ending Page	638
Page Count	4
File Format	PDF
ISSN	00970549
Journal	Neuroscience and Behavioral Physiology
Volume Number	39
Issue Number	7
e-ISSN	1573899X
Language	English
Publisher	Springer US
Publisher Date	2009-07-21
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	tic Tourette’s syndrome Behavioural Sciences Neurobiology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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Neuroimmune Aspects of the Pathogenesis of Tourette’s Syndrome and Experience in the Use of Immunoglobulins in Children