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| Content Provider | Springer Nature Link |
|---|---|
| Author | Alfimova, M. V. Golimbet, V. E. Korovaitseva, G. I. Lezheiko, T. V. Gabaeva, M. V. Oleichik, I. V. Stolyarov, S. A. |
| Copyright Year | 2016 |
| Abstract | Objective. The brain-derived neurotrophic factor gene (BDNF) is a presumptive candidate gene for schizophrenia. Results from many studies have pointed to the absence of any association between this gene and disease, though they have supported a contribution of the Val66Met BDNF polymorphism to variance in the individual features of schizophrenia. The authors suggested that this contribution results from the involvement of the gene in forming cognitive reserves, which have protective effects on various aspects of the disease. This protective effect should be apparent, among others, as relative conservation of cognitive functions in schizophrenia patients with the favorable BDNF Val66Met genotype, as well as in the accumulation of the favorable genotype in unaffected relatives of patients and healthy subjects. The aim of the present work was to test BDNF in terms of meeting the criteria for being a gene for cognitive reserves. Materials and methods. A total of 169 patients with schizophrenia spectrum disorders were studied, along with 320 first-degree relatives and a corresponding control group. Molecular genetic and experimental psychological study methods were used. Results and conclusions. The polymorphism studied here had no influence on verbal memory, executive functions, or the overall index of cognitive deficit in the patients. Furthermore, there were no significant differences in the frequencies of the BDNF Val66Met genotype in first-degree relatives as compared with patients and healthy subjects without any inherited burden of psychoses. These data do not support the hypothesis that BDNF is a gene for cognitive reserves. |
| Starting Page | 534 |
| Ending Page | 538 |
| Page Count | 5 |
| File Format | |
| ISSN | 00970549 |
| Journal | Neuroscience and Behavioral Physiology |
| Volume Number | 46 |
| Issue Number | 5 |
| e-ISSN | 1573899X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2016-05-07 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | brain-derived neurotrophic factor BDNF Val66Met polymorphism schizophrenia cognitive reserves cognitive deficit Neurosciences Neurobiology Behavioral Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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