NDLI: Modeling physicochemical interactions affecting in vitro cellular dosimetry of engineered nanomaterials: application to nanosilver

Content Provider	Springer Nature Link
Author	Mukherjee, Dwaipayan Leo, Bey Fen Royce, Steven G. Porter, Alexandra E. Ryan, Mary P. Schwander, Stephan Chung, Kian Fan Tetley, Teresa D. Zhang, Junfeng Georgopoulos, Pas G.
Copyright Year	2014
Abstract	Engineered nanomaterials (ENMs) possess unique characteristics affecting their interactions in biological media and biological tissues. Systematic investigation of the effects of particle properties on biological toxicity requires a comprehensive modeling framework which can be used to predict ENM particokinetics in a variety of media. The Agglomeration-diffusion-sedimentation-reaction model (ADSRM) described here is stochastic, using a direct simulation Monte Carlo method to study the evolution of nanoparticles in biological media, as they interact with each other and with the media over time. Nanoparticle diffusion, gravitational settling, agglomeration, and dissolution are treated in a mechanistic manner with focus on silver ENMs (AgNPs). The ADSRM model utilizes particle properties such as size, density, zeta potential, and coating material, along with medium properties like density, viscosity, ionic strength, and pH, to model evolving patterns in a population of ENMs along with their interaction with associated ions and molecules. The model predictions for agglomeration and dissolution are compared with in vitro measurements for various types of ENMs, coating materials, and incubation media, and are found to be overall consistent with measurements. The model has been implemented for an in vitro case in cell culture systems to inform in vitro dosimetry for toxicology studies, and can be directly extended to other biological systems, including in vivo tissue sub-systems by suitably modifying system geometry.
Starting Page	1
Ending Page	16
Page Count	16
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	16
Issue Number	10
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-09-07
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Engineered nanomaterials Agglomeration Dissolution Settling Monte Carlo Cellular dosimetry Modeling and simulation Instrumentation Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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