NDLI: Combination of CuO nanoparticles and fluconazole: preparation, characterization, and antifungal activity against Candida albicans

Content Provider	Springer Nature Link
Author	Weitz, Iris S. Maoz, Michal Panitz, Daniel Eichler, Sigal Segal, Ester
Copyright Year	2015
Abstract	Combination therapy becomes an important strategy in the management of invasive fungal infections and emergence of resistant fungi mutants. In this work, we examine the combination of copper oxide (CuO) nanoparticles (NPs) with fluconazole as potential treatment against the pathogenic fungi, Candida albicans. CuO NPs (~7 nm in size) were synthesized with acetate ligands assembled on their surface, as shown by both thermal gravimetric analysis and FTIR spectroscopy. Unlike the commercial CuO (both bulk and 50 nm particles), that are poorly dispersed in water, the interaction with water allows the fine dispersion of the coated CuO NPs and their excellent colloidal stability. The addition of fluconazole to the aqueous CuO dispersion induced spontaneous self-assembly of the NPs into linear pearl-like chains network, shown by cryogenic transmission electron microscopy (cryo-TEM). The antifungal activity of the CuO NPs and their combination with fluconazole (fluconazole–CuO NPs) was studied against C. albicans. The best MIC values were obtained at concentrations as low as 0.2 and 0.3 mg/mL, respectively. The results suggest that fluconazole–CuO NPs can provide a potential alternative treatment for C. albicans infections.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	17
Issue Number	8
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-08-20
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Copper oxide Nanoparticles Antifungal Candida albicans Fluconazole Functionalization Health effects Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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