NDLI: Assessment of the systemic distribution of a bioconjugated anti-Her2 magnetic nanoparticle in a breast cancer model by means of magnetic resonance imaging

Content Provider	Springer Nature Link
Author	Huerta Núñez, L. F. E. Villanueva Lopez, G. Cleva Morales Guadarrama, A. Soto, S. López, J. Silva, J. G. Perez Vielma, N. Sacristán, E. Gudiño Zayas, Marco E. González, C. A.
Copyright Year	2016
Abstract	The aim of this study was to determine the systemic distribution of magnetic nanoparticles of 100 nm diameter (MNPs) coupled to a specific monoclonal antibody anti-Her2 in an experimental breast cancer (BC) model. The study was performed in two groups of Sprague–Dawley rats: control (n = 6) and BC chemically induced (n = 3). Bioconjugated “anti-Her2-MNPs” were intravenously administered, and magnetic resonance imaging (MRI) monitored its systemic distribution at seven times after administration. Non-heme iron presence associated with the location of the bioconjugated anti-Her2-MNPs in splenic, hepatic, cardiac and tumor tissues was detected by Perl’s Prussian blue (PPB) stain. Optical density measurements were used to semiquantitatively determine the iron presence in tissues on the basis of a grayscale values integration of T1 and T2 MRI sequence images. The results indicated a delayed systemic distribution of MNPs in cancer compared to healthy conditions with a maximum concentration of MNPs in cancer tissue at 24 h post-infusion.
Starting Page	1
Ending Page	11
Page Count	11
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	18
Issue Number	9
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-09-22
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Breast cancer Magnetic nanoparticles Anti-Her2 Systemic distribution Magnetic resonance imaging Nanomedicine Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Lasers, Photonics, Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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